The 2015 European Society of Cardiology (ESC) Guidelines for the Management of Infective Endocarditis provide comprehensive guidance on the prevention, diagnosis, and treatment of infective endocarditis (IE). The guidelines are endorsed by the European Association for Cardio-Thoracic Surgery (EACTS) and the European Association of Nuclear Medicine (EANM). The task force, led by Gilbert Habib and Patrizio Lancellotti, includes experts from various European countries and specialties. The guidelines emphasize the importance of a multidisciplinary approach, known as the "Endocarditis Team," involving cardiologists, cardiac surgeons, infectious disease specialists, and other specialists. They recommend restricting antibiotic prophylaxis to high-risk patients, particularly those with prosthetic valves or a history of IE, and highlight the need for hygiene measures in all patients with cardiac disease. Diagnosis is based on clinical features, laboratory findings, and imaging techniques such as echocardiography, multislice computed tomography (MSCT), magnetic resonance imaging (MRI), and nuclear imaging. Echocardiography is the primary tool for diagnosis, with transoesophageal echocardiography (TOE) being particularly useful in difficult cases. Treatment guidelines cover antimicrobial therapy, surgical management, and follow-up. The guidelines also address specific complications, such as heart failure, uncontrolled infection, and embolism, and provide recommendations for managing IE in various patient groups, including those with congenital heart disease, during pregnancy, and with prosthetic heart valves. The guidelines aim to assist healthcare professionals in making informed decisions and improving patient outcomes, while emphasizing the importance of individual clinical judgment and adherence to local guidelines and regulations.The 2015 European Society of Cardiology (ESC) Guidelines for the Management of Infective Endocarditis provide comprehensive guidance on the prevention, diagnosis, and treatment of infective endocarditis (IE). The guidelines are endorsed by the European Association for Cardio-Thoracic Surgery (EACTS) and the European Association of Nuclear Medicine (EANM). The task force, led by Gilbert Habib and Patrizio Lancellotti, includes experts from various European countries and specialties. The guidelines emphasize the importance of a multidisciplinary approach, known as the "Endocarditis Team," involving cardiologists, cardiac surgeons, infectious disease specialists, and other specialists. They recommend restricting antibiotic prophylaxis to high-risk patients, particularly those with prosthetic valves or a history of IE, and highlight the need for hygiene measures in all patients with cardiac disease. Diagnosis is based on clinical features, laboratory findings, and imaging techniques such as echocardiography, multislice computed tomography (MSCT), magnetic resonance imaging (MRI), and nuclear imaging. Echocardiography is the primary tool for diagnosis, with transoesophageal echocardiography (TOE) being particularly useful in difficult cases. Treatment guidelines cover antimicrobial therapy, surgical management, and follow-up. The guidelines also address specific complications, such as heart failure, uncontrolled infection, and embolism, and provide recommendations for managing IE in various patient groups, including those with congenital heart disease, during pregnancy, and with prosthetic heart valves. The guidelines aim to assist healthcare professionals in making informed decisions and improving patient outcomes, while emphasizing the importance of individual clinical judgment and adherence to local guidelines and regulations.