The article discusses the role of AMPK (AMP-activated protein kinase) in the crosstalk between tumor cell energy metabolism and the immune microenvironment, highlighting its significance in cancer immunotherapy. AMPK is a key regulator of metabolic pathways and plays a crucial role in modulating the energy metabolism of both tumor cells and immune cells. The dynamic changes in cell metabolism during tumor progression significantly affect the activity, state, and function of tumor cells and immune cells. AMPK's activation can enhance the metabolic adaptability of tumor cells and immune cells, influencing their growth, proliferation, and function. Specifically, AMPK can regulate glucose and lipid metabolism, mitochondrial function, and autophagy, which in turn affect the composition and activity of the tumor immune microenvironment (TIME). This regulation impacts the differentiation and function of various immune cells, such as T cells, B cells, NK cells, and macrophages, thereby enhancing anti-tumor immunity and improving the efficacy of immunotherapy. The article also explores the potential of AMPK as a therapeutic target for enhancing the effectiveness of tumor immunotherapy, emphasizing the need for further research to understand the specific mechanisms by which AMPK regulates metabolic reprogramming in the TIME.The article discusses the role of AMPK (AMP-activated protein kinase) in the crosstalk between tumor cell energy metabolism and the immune microenvironment, highlighting its significance in cancer immunotherapy. AMPK is a key regulator of metabolic pathways and plays a crucial role in modulating the energy metabolism of both tumor cells and immune cells. The dynamic changes in cell metabolism during tumor progression significantly affect the activity, state, and function of tumor cells and immune cells. AMPK's activation can enhance the metabolic adaptability of tumor cells and immune cells, influencing their growth, proliferation, and function. Specifically, AMPK can regulate glucose and lipid metabolism, mitochondrial function, and autophagy, which in turn affect the composition and activity of the tumor immune microenvironment (TIME). This regulation impacts the differentiation and function of various immune cells, such as T cells, B cells, NK cells, and macrophages, thereby enhancing anti-tumor immunity and improving the efficacy of immunotherapy. The article also explores the potential of AMPK as a therapeutic target for enhancing the effectiveness of tumor immunotherapy, emphasizing the need for further research to understand the specific mechanisms by which AMPK regulates metabolic reprogramming in the TIME.