This case series report describes the clinical and epidemiological features of 10 children with 2019 novel coronavirus (2019-nCoV) infection outside of Wuhan, China. The study was conducted between January 19 and February 3, 2020, at various hospitals in Shanghai, Hainan, Hefei, and Qingdao. All patients were hospitalized and tested for 2019-nCoV using real-time RT-PCR. The mean age of the patients was 74 months, with a male-to-female ratio of 1:1.5. Common symptoms included fever (80%), cough (60%), sore throat (40%), and stuffy nose (30%). None of the patients experienced diarrhea or dyspnea. Fever resolved within 24 hours, and chest radiographs showed unilateral patchy infiltrates in 40% of the patients. Laboratory findings were generally mild, and all patients received symptomatic treatment. 2019-nCoV RNA was detected in nasopharyngeal and throat swabs within 4-48 hours after symptom onset, and it persisted for an average of 12 days. Fecal samples from 5 patients (83.3%) tested positive for 2019-nCoV RNA, indicating prolonged virus shedding. The study highlights the importance of early recognition and infection control measures, as well as the potential for human-to-human transmission in children. The findings suggest that children may have a longer incubation period and that the gastrointestinal tract could be another site of viral replication. Further research and surveillance are needed to understand the clinical characteristics and natural history of 2019-nCoV infection in children.This case series report describes the clinical and epidemiological features of 10 children with 2019 novel coronavirus (2019-nCoV) infection outside of Wuhan, China. The study was conducted between January 19 and February 3, 2020, at various hospitals in Shanghai, Hainan, Hefei, and Qingdao. All patients were hospitalized and tested for 2019-nCoV using real-time RT-PCR. The mean age of the patients was 74 months, with a male-to-female ratio of 1:1.5. Common symptoms included fever (80%), cough (60%), sore throat (40%), and stuffy nose (30%). None of the patients experienced diarrhea or dyspnea. Fever resolved within 24 hours, and chest radiographs showed unilateral patchy infiltrates in 40% of the patients. Laboratory findings were generally mild, and all patients received symptomatic treatment. 2019-nCoV RNA was detected in nasopharyngeal and throat swabs within 4-48 hours after symptom onset, and it persisted for an average of 12 days. Fecal samples from 5 patients (83.3%) tested positive for 2019-nCoV RNA, indicating prolonged virus shedding. The study highlights the importance of early recognition and infection control measures, as well as the potential for human-to-human transmission in children. The findings suggest that children may have a longer incubation period and that the gastrointestinal tract could be another site of viral replication. Further research and surveillance are needed to understand the clinical characteristics and natural history of 2019-nCoV infection in children.