Elsevier established a free COVID-19 resource center in January 2020, offering English and Mandarin information on the virus. The center is hosted on Elsevier Connect, a public news and information website. Elsevier grants permission to freely share its COVID-19 research in PubMed Central and other public repositories for research use. A study conducted in May 2020 surveyed 2,006 U.S. adults to assess willingness to get a COVID-19 vaccine. Overall, 69% of participants were willing to get vaccinated. Factors increasing willingness included belief in healthcare provider recommendations, moderate or liberal political views, and higher perceived likelihood, severity, and effectiveness of infection and vaccine. Lower willingness was associated with being non-Latinx Black, higher perceived vaccine harms, and being female. The study found that vaccine acceptability varied by demographics, with lower rates among non-Latinx Black individuals, lower-income groups, and conservatives. Provider recommendations were a key factor in vaccine acceptance. Health beliefs, such as perceived vaccine effectiveness and severity of infection, also influenced willingness. The study highlights the importance of addressing these factors to improve vaccine uptake. The findings suggest that many U.S. adults are willing to get a COVID-19 vaccine, but acceptability should be monitored as development continues. The study provides insights for future efforts to increase vaccine acceptance and uptake. The research underscores the role of healthcare providers and modifiable health beliefs in vaccine acceptance. The study also notes that financial barriers and vaccine side effects may affect willingness, emphasizing the need for cost-free or low-cost vaccination options.Elsevier established a free COVID-19 resource center in January 2020, offering English and Mandarin information on the virus. The center is hosted on Elsevier Connect, a public news and information website. Elsevier grants permission to freely share its COVID-19 research in PubMed Central and other public repositories for research use. A study conducted in May 2020 surveyed 2,006 U.S. adults to assess willingness to get a COVID-19 vaccine. Overall, 69% of participants were willing to get vaccinated. Factors increasing willingness included belief in healthcare provider recommendations, moderate or liberal political views, and higher perceived likelihood, severity, and effectiveness of infection and vaccine. Lower willingness was associated with being non-Latinx Black, higher perceived vaccine harms, and being female. The study found that vaccine acceptability varied by demographics, with lower rates among non-Latinx Black individuals, lower-income groups, and conservatives. Provider recommendations were a key factor in vaccine acceptance. Health beliefs, such as perceived vaccine effectiveness and severity of infection, also influenced willingness. The study highlights the importance of addressing these factors to improve vaccine uptake. The findings suggest that many U.S. adults are willing to get a COVID-19 vaccine, but acceptability should be monitored as development continues. The study provides insights for future efforts to increase vaccine acceptance and uptake. The research underscores the role of healthcare providers and modifiable health beliefs in vaccine acceptance. The study also notes that financial barriers and vaccine side effects may affect willingness, emphasizing the need for cost-free or low-cost vaccination options.