A study investigated the effects of acute and repeated ashwagandha supplementation on cognitive function and mood in healthy young adults. The study involved 59 participants who were randomly assigned to receive either a placebo or 225 mg of liposomal ashwagandha (Withania somnifera) root and leaf extract. Cognitive function was assessed using the COMPASS cognitive test battery, which included tasks such as word recall, word recognition, choice reaction time, picture recognition, digit vigilance, Corsi Block, and Stroop test. Mood was evaluated using the Profile of Mood States (POMS) questionnaire. Results showed that ashwagandha supplementation improved several cognitive function measures, including word recall, choice reaction time, picture recognition, digit vigilance, and Stroop test performance, compared to the placebo group. Additionally, ashwagandha supplementation was associated with reduced tension and fatigue scores on the POMS questionnaire. These improvements were observed both immediately after a single dose and after 30 days of daily supplementation. The study also examined markers of health and safety, including blood cell counts and serum metabolic panel results. While no significant differences were found in most blood markers, ashwagandha supplementation was associated with a significant increase in high-density lipoprotein (HDL) cholesterol and a decrease in the HDL to total cholesterol ratio. Additionally, BUN and total bilirubin levels were lower, and total protein and calcium levels were higher in the ashwagandha group. The study concluded that ashwagandha supplementation (225 mg) may improve cognitive function, including memory, attention, and executive function, while reducing perceptions of tension and fatigue in healthy young individuals. The findings support the potential of ashwagandha as a nootropic supplement for improving cognitive performance and mood in healthy populations. Further research is needed to explore the long-term effects of ashwagandha supplementation and its potential benefits in older adults and individuals with cognitive impairments.A study investigated the effects of acute and repeated ashwagandha supplementation on cognitive function and mood in healthy young adults. The study involved 59 participants who were randomly assigned to receive either a placebo or 225 mg of liposomal ashwagandha (Withania somnifera) root and leaf extract. Cognitive function was assessed using the COMPASS cognitive test battery, which included tasks such as word recall, word recognition, choice reaction time, picture recognition, digit vigilance, Corsi Block, and Stroop test. Mood was evaluated using the Profile of Mood States (POMS) questionnaire. Results showed that ashwagandha supplementation improved several cognitive function measures, including word recall, choice reaction time, picture recognition, digit vigilance, and Stroop test performance, compared to the placebo group. Additionally, ashwagandha supplementation was associated with reduced tension and fatigue scores on the POMS questionnaire. These improvements were observed both immediately after a single dose and after 30 days of daily supplementation. The study also examined markers of health and safety, including blood cell counts and serum metabolic panel results. While no significant differences were found in most blood markers, ashwagandha supplementation was associated with a significant increase in high-density lipoprotein (HDL) cholesterol and a decrease in the HDL to total cholesterol ratio. Additionally, BUN and total bilirubin levels were lower, and total protein and calcium levels were higher in the ashwagandha group. The study concluded that ashwagandha supplementation (225 mg) may improve cognitive function, including memory, attention, and executive function, while reducing perceptions of tension and fatigue in healthy young individuals. The findings support the potential of ashwagandha as a nootropic supplement for improving cognitive performance and mood in healthy populations. Further research is needed to explore the long-term effects of ashwagandha supplementation and its potential benefits in older adults and individuals with cognitive impairments.