This study evaluates the performance of ChatGPT-3.5 and ChatGPT-4 in addressing complex clinical and ethical dilemmas, aiming to assess their potential role in healthcare decision-making. The research involved 4 specialized physicians formulating 176 real-world clinical questions, which were then assessed by 8 senior physicians and residents on a 1-5 scale across five categories: accuracy, relevance, clarity, utility, and comprehensiveness. Both models received high mean scores, with GPT-4 outperforming GPT-3.5 across all rating dimensions. Seniors consistently rated responses higher than residents for both models, particularly in terms of benefits and completeness. Ethical queries received the highest ratings for both models. The study concludes that ChatGPT has promising potential to assist physicians in medical issues, enhancing diagnostics, treatments, and ethics. However, it must complement, not replace, human expertise, and further research is needed to ensure safe and effective implementation in clinical settings.This study evaluates the performance of ChatGPT-3.5 and ChatGPT-4 in addressing complex clinical and ethical dilemmas, aiming to assess their potential role in healthcare decision-making. The research involved 4 specialized physicians formulating 176 real-world clinical questions, which were then assessed by 8 senior physicians and residents on a 1-5 scale across five categories: accuracy, relevance, clarity, utility, and comprehensiveness. Both models received high mean scores, with GPT-4 outperforming GPT-3.5 across all rating dimensions. Seniors consistently rated responses higher than residents for both models, particularly in terms of benefits and completeness. Ethical queries received the highest ratings for both models. The study concludes that ChatGPT has promising potential to assist physicians in medical issues, enhancing diagnostics, treatments, and ethics. However, it must complement, not replace, human expertise, and further research is needed to ensure safe and effective implementation in clinical settings.