This study aimed to determine the incidence and mortality of bullous pemphigoid and pemphigus vulgaris in the United Kingdom. Using data from the Health Improvement Network, a large UK general practice database, researchers identified 869 cases of bullous pemphigoid and 138 cases of pemphigus vulgaris. The median age at diagnosis for bullous pemphigoid was 80 years, with 61% female patients, while for pemphigus vulgaris, it was 71 years, with 66% female patients. Incidences were 4.3 per 100,000 person-years for bullous pemphigoid and 0.7 per 100,000 person-years for pemphigus vulgaris. Both diseases showed increasing incidence over time, with an average yearly increase of 17% for bullous pemphigoid and 11% for pemphigus vulgaris. The risk of death was significantly higher in patients with bullous pemphigoid (adjusted hazard ratio=2.3) and pemphigus vulgaris (adjusted hazard ratio=3.3) compared to controls. The study suggests that the incidence of these diseases is increasing, and previous estimates may have underestimated the risk of death associated with these conditions.This study aimed to determine the incidence and mortality of bullous pemphigoid and pemphigus vulgaris in the United Kingdom. Using data from the Health Improvement Network, a large UK general practice database, researchers identified 869 cases of bullous pemphigoid and 138 cases of pemphigus vulgaris. The median age at diagnosis for bullous pemphigoid was 80 years, with 61% female patients, while for pemphigus vulgaris, it was 71 years, with 66% female patients. Incidences were 4.3 per 100,000 person-years for bullous pemphigoid and 0.7 per 100,000 person-years for pemphigus vulgaris. Both diseases showed increasing incidence over time, with an average yearly increase of 17% for bullous pemphigoid and 11% for pemphigus vulgaris. The risk of death was significantly higher in patients with bullous pemphigoid (adjusted hazard ratio=2.3) and pemphigus vulgaris (adjusted hazard ratio=3.3) compared to controls. The study suggests that the incidence of these diseases is increasing, and previous estimates may have underestimated the risk of death associated with these conditions.