Cervical cancer incidence, mortality, and burden in China: a time-trend analysis and comparison with England and India based on the global burden of disease study 2019

Cervical cancer incidence, mortality, and burden in China: a time-trend analysis and comparison with England and India based on the global burden of disease study 2019

06 March 2024 | Siyu Wu, Jun Jiao, Xiaoyu Yue and Yaping Wang
This study analyzes the incidence, mortality, and disease burden of cervical cancer in China, England, and India from 1990 to 2019, and projects trends for 2020–2030 using the Global Burden of Disease (GBD) 2019 database. Cervical cancer is the fourth most common cancer globally, with approximately 604,000 new cases and 342,000 deaths worldwide in 2020. It is primarily caused by persistent infection with high-risk human papillomavirus (HPV) types. The study found that the global incidence of cervical cancer increased by 68.5% from 1990 to 2019. In 2019, the age-standardized incidence rate (ASIR) and age-standardized death rate (ASDR) in China were higher than in India but lower than in England. The ASIR in India decreased from 16.65 to 13.1 per 100,000 between 1990 and 2019, while the ASDR decreased from 10.9 to 7.38. In England, both ASIR and ASDR decreased significantly over the period. China's ASIR increased by 1.61% per year, while India's ASIR showed a gradual increase from 1990 to 2012, followed by a gradual rise to 14.86 by 2030. The ASDR in India decreased from 1990 to 2012, then gradually declined to 7.39 by 2030. The study also identified unsafe sex and smoking as major risk factors for cervical cancer. Projections indicate that ASIR and ASDR in China and England will continue to decline, while India's ASIR is still on an upward trend and ASDR is on a downward trend. The study highlights the need for improved prevention and control measures in China and India, particularly in poorer and remote areas. The findings suggest that while England has made significant progress, China and India still face a substantial burden of cervical cancer. The study underscores the importance of public education and awareness to reduce the disease burden. The research provides valuable insights for developing policies to reduce the impact of cervical cancer in the future.This study analyzes the incidence, mortality, and disease burden of cervical cancer in China, England, and India from 1990 to 2019, and projects trends for 2020–2030 using the Global Burden of Disease (GBD) 2019 database. Cervical cancer is the fourth most common cancer globally, with approximately 604,000 new cases and 342,000 deaths worldwide in 2020. It is primarily caused by persistent infection with high-risk human papillomavirus (HPV) types. The study found that the global incidence of cervical cancer increased by 68.5% from 1990 to 2019. In 2019, the age-standardized incidence rate (ASIR) and age-standardized death rate (ASDR) in China were higher than in India but lower than in England. The ASIR in India decreased from 16.65 to 13.1 per 100,000 between 1990 and 2019, while the ASDR decreased from 10.9 to 7.38. In England, both ASIR and ASDR decreased significantly over the period. China's ASIR increased by 1.61% per year, while India's ASIR showed a gradual increase from 1990 to 2012, followed by a gradual rise to 14.86 by 2030. The ASDR in India decreased from 1990 to 2012, then gradually declined to 7.39 by 2030. The study also identified unsafe sex and smoking as major risk factors for cervical cancer. Projections indicate that ASIR and ASDR in China and England will continue to decline, while India's ASIR is still on an upward trend and ASDR is on a downward trend. The study highlights the need for improved prevention and control measures in China and India, particularly in poorer and remote areas. The findings suggest that while England has made significant progress, China and India still face a substantial burden of cervical cancer. The study underscores the importance of public education and awareness to reduce the disease burden. The research provides valuable insights for developing policies to reduce the impact of cervical cancer in the future.
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