This study assesses the chemical quality and associated human health risks of drinking water sources in the Gutai Mountains, Romania. The research analyzed six physico-chemical indicators, nine anions, and twenty-one metals from 120 groundwater samples collected over 12 months. Results showed that waters were rich in NH4+ and NO2-, exceeding recommended limits, while some samples contained high levels of As, Cd, Mn, and Pb, though below drinking water standards. Heavy metal pollution indices indicated that over 50% of samples had medium pollution levels. Geological and human activities were identified as major contributors to chemical enrichment. A human health risk assessment revealed no significant non-carcinogenic risks for As, Mn, Cd, and Cu. The study highlights the importance of clean drinking water and provides valuable insights into potential pollution and health risks in mountain areas.This study assesses the chemical quality and associated human health risks of drinking water sources in the Gutai Mountains, Romania. The research analyzed six physico-chemical indicators, nine anions, and twenty-one metals from 120 groundwater samples collected over 12 months. Results showed that waters were rich in NH4+ and NO2-, exceeding recommended limits, while some samples contained high levels of As, Cd, Mn, and Pb, though below drinking water standards. Heavy metal pollution indices indicated that over 50% of samples had medium pollution levels. Geological and human activities were identified as major contributors to chemical enrichment. A human health risk assessment revealed no significant non-carcinogenic risks for As, Mn, Cd, and Cu. The study highlights the importance of clean drinking water and provides valuable insights into potential pollution and health risks in mountain areas.