A study published in *Biol Psychiatry* (2012) investigates the relationship between the efficacy of transcranial magnetic stimulation (TMS) targets for depression and intrinsic functional connectivity with the subgenual cingulate. The research used resting-state fMRI data from 98 healthy subjects to analyze functional connectivity between various left dorsolateral prefrontal cortex (DLPFC) TMS targets and the subgenual cingulate. The findings showed that TMS sites with better clinical efficacy were more negatively correlated (anticorrelated) with the subgenual cingulate. This anticorrelation was most pronounced in Brodmann area 46 (BA46). These results were confirmed in 13 patients with depression, showing that optimized TMS coordinates based on this connectivity pattern were effective. The study suggests that the antidepressant effect of TMS may be related to the anticorrelation between the DLPFC and the subgenual cingulate, which could be a key factor in the therapeutic response. The findings support the use of connectivity-based targeting strategies for focal brain stimulation, potentially improving clinical outcomes for depression. The results also highlight the importance of intrinsic anticorrelated networks in depression and suggest that these networks could be targeted in future treatments. The study emphasizes the need for further research to validate these findings in clinical trials and to explore their applicability across various neurological and psychiatric conditions.A study published in *Biol Psychiatry* (2012) investigates the relationship between the efficacy of transcranial magnetic stimulation (TMS) targets for depression and intrinsic functional connectivity with the subgenual cingulate. The research used resting-state fMRI data from 98 healthy subjects to analyze functional connectivity between various left dorsolateral prefrontal cortex (DLPFC) TMS targets and the subgenual cingulate. The findings showed that TMS sites with better clinical efficacy were more negatively correlated (anticorrelated) with the subgenual cingulate. This anticorrelation was most pronounced in Brodmann area 46 (BA46). These results were confirmed in 13 patients with depression, showing that optimized TMS coordinates based on this connectivity pattern were effective. The study suggests that the antidepressant effect of TMS may be related to the anticorrelation between the DLPFC and the subgenual cingulate, which could be a key factor in the therapeutic response. The findings support the use of connectivity-based targeting strategies for focal brain stimulation, potentially improving clinical outcomes for depression. The results also highlight the importance of intrinsic anticorrelated networks in depression and suggest that these networks could be targeted in future treatments. The study emphasizes the need for further research to validate these findings in clinical trials and to explore their applicability across various neurological and psychiatric conditions.