The study investigates the therapeutic potential of engineered extracellular vesicles (EVs) containing metformin (Met-EV) for aged wound repair. Aging skin is characterized by poor wound healing due to accumulated senescent cells (SnCs) and disrupted energy metabolism. Met-EV was found to enhance aged mouse skin repair, reduce cellular senescence, and restore cell functions. Met-EV remodeling of ATP metabolism, including reduced glycolysis and enhanced oxidative phosphorylation (OXPHOS), was observed. Met-EV also rescued senescence-induced mitochondrial dysfunction and suppressed mitophagy, indicating its role in mitochondrial function via mitophagy. The study suggests that disturbed energy metabolism in aged tissue repair is a potential therapeutic target, and Met-EV could be a promising therapeutic approach.The study investigates the therapeutic potential of engineered extracellular vesicles (EVs) containing metformin (Met-EV) for aged wound repair. Aging skin is characterized by poor wound healing due to accumulated senescent cells (SnCs) and disrupted energy metabolism. Met-EV was found to enhance aged mouse skin repair, reduce cellular senescence, and restore cell functions. Met-EV remodeling of ATP metabolism, including reduced glycolysis and enhanced oxidative phosphorylation (OXPHOS), was observed. Met-EV also rescued senescence-induced mitochondrial dysfunction and suppressed mitophagy, indicating its role in mitochondrial function via mitophagy. The study suggests that disturbed energy metabolism in aged tissue repair is a potential therapeutic target, and Met-EV could be a promising therapeutic approach.