The study reports the development of a 0.6% Ir/CeO2-x catalyst for the dry reforming of methane (DRM), which efficiently converts CH4 and CO2 into syngas. The catalyst exhibits high conversion rates of CH4 (~72%) and CO2 (~82%) and a reaction rate of ~973 μmolCH4 gcat-1s-1 at 700 °C, demonstrating excellent performance comparable to state-of-the-art catalysts. The interfacial structure (Ir6+-Ov-Ce3+) between the metal and support is identified as the intrinsic active center, facilitating CH4 dissociation and CH2* oxidation without coke formation. This structure enhances catalytic activity and stability, making the catalyst a promising candidate for high-value utilization of carbon resources. The findings are supported by in situ spectroscopic characterization and theoretical calculations, highlighting the importance of the interfacial synergistic catalysis in DRM reactions.The study reports the development of a 0.6% Ir/CeO2-x catalyst for the dry reforming of methane (DRM), which efficiently converts CH4 and CO2 into syngas. The catalyst exhibits high conversion rates of CH4 (~72%) and CO2 (~82%) and a reaction rate of ~973 μmolCH4 gcat-1s-1 at 700 °C, demonstrating excellent performance comparable to state-of-the-art catalysts. The interfacial structure (Ir6+-Ov-Ce3+) between the metal and support is identified as the intrinsic active center, facilitating CH4 dissociation and CH2* oxidation without coke formation. This structure enhances catalytic activity and stability, making the catalyst a promising candidate for high-value utilization of carbon resources. The findings are supported by in situ spectroscopic characterization and theoretical calculations, highlighting the importance of the interfacial synergistic catalysis in DRM reactions.