This systematic review examines the factors influencing where terminally ill cancer patients die. The study analyzed 58 studies involving over 1.5 million patients from 13 countries. High strength evidence was found for 17 factors affecting place of death, with six strongly associated with dying at home: low functional status (odds ratios 2.29-11.1), patient preferences (2.19-8.38), home care (1.37-5.1), intensity of home care (1.06-8.65), living with relatives (1.78-7.85), and extended family support (2.28-5.47). These factors covered illness-related, individual, and environmental aspects, with social support being the most important. The review highlights the complex network of factors influencing where patients with cancer die. These include illness-related factors such as non-solid tumours, disease duration, and functional status; individual factors like age, gender, and preferences; and environmental factors such as home care availability, social support, and macrosocial factors like cultural and policy influences. The study emphasizes the importance of social support and home care in facilitating home death. The findings suggest that while preferences and home care are important, there is a gap between patient preferences and actual place of death, often due to fragmented research and conflicting findings. The review recommends future policies and clinical practices should focus on empowering families, public education, and improving home care, risk assessment, and training for end-of-life care. The study also identifies limitations, including the completeness of the search, heterogeneity between studies, and reliance on retrospective data. It calls for further research to evaluate the effectiveness of initiatives aimed at improving home death, particularly in addressing disparities in access to home care and the need for preventive strategies like public awareness campaigns. The model developed in the study provides an evidence-based framework for understanding the factors influencing where terminally ill patients die, emphasizing the importance of social support and home care in achieving a dignified death at home.This systematic review examines the factors influencing where terminally ill cancer patients die. The study analyzed 58 studies involving over 1.5 million patients from 13 countries. High strength evidence was found for 17 factors affecting place of death, with six strongly associated with dying at home: low functional status (odds ratios 2.29-11.1), patient preferences (2.19-8.38), home care (1.37-5.1), intensity of home care (1.06-8.65), living with relatives (1.78-7.85), and extended family support (2.28-5.47). These factors covered illness-related, individual, and environmental aspects, with social support being the most important. The review highlights the complex network of factors influencing where patients with cancer die. These include illness-related factors such as non-solid tumours, disease duration, and functional status; individual factors like age, gender, and preferences; and environmental factors such as home care availability, social support, and macrosocial factors like cultural and policy influences. The study emphasizes the importance of social support and home care in facilitating home death. The findings suggest that while preferences and home care are important, there is a gap between patient preferences and actual place of death, often due to fragmented research and conflicting findings. The review recommends future policies and clinical practices should focus on empowering families, public education, and improving home care, risk assessment, and training for end-of-life care. The study also identifies limitations, including the completeness of the search, heterogeneity between studies, and reliance on retrospective data. It calls for further research to evaluate the effectiveness of initiatives aimed at improving home death, particularly in addressing disparities in access to home care and the need for preventive strategies like public awareness campaigns. The model developed in the study provides an evidence-based framework for understanding the factors influencing where terminally ill patients die, emphasizing the importance of social support and home care in achieving a dignified death at home.