The study provides a comprehensive analysis of cancer incidence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) for 32 cancer groups in 195 countries and territories from 1990 to 2015. Key findings include: - In 2015, there were 17.5 million cancer cases and 8.7 million cancer deaths globally. - Cancer caused 208.3 million DALYs worldwide in 2015, with 96% from YLLs and 4% from YLDs. - Prostate cancer was the most common cancer globally, followed by tracheal, bronchus, and lung cancer (TBL), and colorectal cancer. - Breast cancer was the most common cancer among women, followed by TBL, colorectal, and prostate cancer among men. - Between 2005 and 2015, age-standardized incidence rates for all cancers combined increased in 174 countries or territories, while age-standardized death rates decreased in 140 countries or territories. - The largest increases in cancer incidence occurred in low SDI countries, followed by low-middle SDI countries. - TBL cancer was the leading cause of cancer deaths and DALYs in men, while breast cancer was the leading cause in women. - Liver cancer remained the second leading cause of cancer YLLs between 2005 and 2015, driven by population growth and aging. - Non-Hodgkin lymphoma (NHL) ranked 11th for cancer YLLs in 2015, with a 56% increase in cases between 2005 and 2015. The study highlights the need for continued efforts in cancer prevention, early diagnosis, and treatment to address the growing burden of cancer globally.The study provides a comprehensive analysis of cancer incidence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) for 32 cancer groups in 195 countries and territories from 1990 to 2015. Key findings include: - In 2015, there were 17.5 million cancer cases and 8.7 million cancer deaths globally. - Cancer caused 208.3 million DALYs worldwide in 2015, with 96% from YLLs and 4% from YLDs. - Prostate cancer was the most common cancer globally, followed by tracheal, bronchus, and lung cancer (TBL), and colorectal cancer. - Breast cancer was the most common cancer among women, followed by TBL, colorectal, and prostate cancer among men. - Between 2005 and 2015, age-standardized incidence rates for all cancers combined increased in 174 countries or territories, while age-standardized death rates decreased in 140 countries or territories. - The largest increases in cancer incidence occurred in low SDI countries, followed by low-middle SDI countries. - TBL cancer was the leading cause of cancer deaths and DALYs in men, while breast cancer was the leading cause in women. - Liver cancer remained the second leading cause of cancer YLLs between 2005 and 2015, driven by population growth and aging. - Non-Hodgkin lymphoma (NHL) ranked 11th for cancer YLLs in 2015, with a 56% increase in cases between 2005 and 2015. The study highlights the need for continued efforts in cancer prevention, early diagnosis, and treatment to address the growing burden of cancer globally.