This study assesses the global, regional, and national burden of liver cirrhosis and other chronic liver diseases from 1990 to 2019, considering five etiologies (hepatitis B, hepatitis C, alcohol use, NAFLD, and other causes), age, gender, and sociodemographic index (SDI). The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study 2019 data were used to analyze mortality, incidence, and disability-adjusted life years (DALYs). In 2019, liver cirrhosis and other chronic liver diseases caused 1,472,011 deaths globally, an increase of 45.32% from 1990. Despite this, the age-standardized death rate declined from 24.43 per 100,000 population in 1990 to 18.00 per 100,000 population in 2019. Eastern Sub-Saharan Africa had the highest age-standardized death rate (44.15 per 100,000 population), while Australasia had the lowest (5.48 per 100,000 population). The incidence rate of liver cirrhosis and other chronic liver diseases attributed to hepatitis B virus declined, while other etiologies showed an increase. Age-standardized death and DALYs rates decreased with higher SDI across different GBD regions and countries. Mortality increased with age and was 1.51 times higher in males than in females globally. The study highlights the need for effective disease control, prevention, and treatment strategies that account for variations in risk factors, age, gender, and regional disparities.This study assesses the global, regional, and national burden of liver cirrhosis and other chronic liver diseases from 1990 to 2019, considering five etiologies (hepatitis B, hepatitis C, alcohol use, NAFLD, and other causes), age, gender, and sociodemographic index (SDI). The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study 2019 data were used to analyze mortality, incidence, and disability-adjusted life years (DALYs). In 2019, liver cirrhosis and other chronic liver diseases caused 1,472,011 deaths globally, an increase of 45.32% from 1990. Despite this, the age-standardized death rate declined from 24.43 per 100,000 population in 1990 to 18.00 per 100,000 population in 2019. Eastern Sub-Saharan Africa had the highest age-standardized death rate (44.15 per 100,000 population), while Australasia had the lowest (5.48 per 100,000 population). The incidence rate of liver cirrhosis and other chronic liver diseases attributed to hepatitis B virus declined, while other etiologies showed an increase. Age-standardized death and DALYs rates decreased with higher SDI across different GBD regions and countries. Mortality increased with age and was 1.51 times higher in males than in females globally. The study highlights the need for effective disease control, prevention, and treatment strategies that account for variations in risk factors, age, gender, and regional disparities.