This systematic review examines the perspectives of patients on healthcare quality in Gulf Cooperation Council (GCC) countries, focusing on six domains: safety, timeliness, efficiency, effectiveness, equitability, and patient-centeredness. The review, conducted from 2012 to 2023, analyzed 22 articles, most of which were from Saudi Arabia. Key findings include common problems such as diagnostic and medication errors, communication issues, missed appointments, long waiting times, and physical environment concerns. Patients perceive healthcare quality as influenced by multiple factors, including location and type of healthcare service providers. Disparities in perceptions were observed between patients attending Primary Health Care (PHC) centers in rural and urban areas. Issues like lack of equitable healthcare delivery and deficiencies in Emergency Medical Services (EMS) effectiveness were recognized as quality concerns by different patient populations. The review provides insights into areas needing improvement and strategies for ensuring patient-centered, safe, equitable, timely, and effective healthcare. Healthcare providers and policymakers in GCC countries can use these findings to plan, assess, and enhance care delivery.This systematic review examines the perspectives of patients on healthcare quality in Gulf Cooperation Council (GCC) countries, focusing on six domains: safety, timeliness, efficiency, effectiveness, equitability, and patient-centeredness. The review, conducted from 2012 to 2023, analyzed 22 articles, most of which were from Saudi Arabia. Key findings include common problems such as diagnostic and medication errors, communication issues, missed appointments, long waiting times, and physical environment concerns. Patients perceive healthcare quality as influenced by multiple factors, including location and type of healthcare service providers. Disparities in perceptions were observed between patients attending Primary Health Care (PHC) centers in rural and urban areas. Issues like lack of equitable healthcare delivery and deficiencies in Emergency Medical Services (EMS) effectiveness were recognized as quality concerns by different patient populations. The review provides insights into areas needing improvement and strategies for ensuring patient-centered, safe, equitable, timely, and effective healthcare. Healthcare providers and policymakers in GCC countries can use these findings to plan, assess, and enhance care delivery.