This paper reviews the development and application of hybrid organic-inorganic materials prepared using the sol-gel technique for biomedical use. The sol-gel technique, a versatile method for creating ceramic oxides at low temperatures through hydrolysis and polycondensation reactions, is highlighted as an innovative approach to producing biocompatible materials. The study focuses on organic-inorganic hybrids, which combine the properties of both organic and inorganic components to enhance biocompatibility, mechanical strength, and chemical stability. The use of plant extracts as organic components is a novel aspect of this research, leveraging their biological activities such as antioxidants, antibacterial properties, and biocompatibility. The paper discusses the advantages and disadvantages of the sol-gel technique, including its adaptability and control over material properties, while also addressing challenges such as production time, cost, and environmental safety. The characterization methods for biomaterials, including FTIR, NMR, SEM, and mechanical testing, are detailed to ensure safety, efficacy, and usefulness in medical applications. The potential applications of these materials in tissue engineering, drug delivery systems, and implants are explored, emphasizing their ability to integrate with biological tissues and reduce adverse reactions. The paper concludes by highlighting the ongoing advancements in the sol-gel technique and its role in creating innovative materials for biomedical and healthcare sectors.This paper reviews the development and application of hybrid organic-inorganic materials prepared using the sol-gel technique for biomedical use. The sol-gel technique, a versatile method for creating ceramic oxides at low temperatures through hydrolysis and polycondensation reactions, is highlighted as an innovative approach to producing biocompatible materials. The study focuses on organic-inorganic hybrids, which combine the properties of both organic and inorganic components to enhance biocompatibility, mechanical strength, and chemical stability. The use of plant extracts as organic components is a novel aspect of this research, leveraging their biological activities such as antioxidants, antibacterial properties, and biocompatibility. The paper discusses the advantages and disadvantages of the sol-gel technique, including its adaptability and control over material properties, while also addressing challenges such as production time, cost, and environmental safety. The characterization methods for biomaterials, including FTIR, NMR, SEM, and mechanical testing, are detailed to ensure safety, efficacy, and usefulness in medical applications. The potential applications of these materials in tissue engineering, drug delivery systems, and implants are explored, emphasizing their ability to integrate with biological tissues and reduce adverse reactions. The paper concludes by highlighting the ongoing advancements in the sol-gel technique and its role in creating innovative materials for biomedical and healthcare sectors.