**IntelliCage: The Development and Perspectives of a Mouse- and User-Friendly Automated Behavioral Test System** The IntelliCage is a home-cage system designed to automate behavioral testing in mice, addressing issues of animal welfare, standardization, reproducibility, and the high workload associated with manual behavioral phenotyping. The system integrates four operant conditioning boxes into the corners of a standard mouse cage, allowing for individual identification and recording of mouse activity using subcutaneously implanted transponders. This setup enables the application of reward and punishment schemes in a social context, reducing handling stress and improving the realism of the testing environment. The development of IntelliCage was driven by four main factors: 1. **Dissatisfaction with standard phenotyping approaches**: Traditional behavioral tests often failed to provide standardized and reproducible results, leading to concerns about the reliability of findings. 2. **Animal welfare**: Standard tests, such as the water maze and shock-induced fear conditioning, were stressful for mice and required frequent handling, which can negatively impact their behavior. 3. **Standardization and reproducibility problems**: The lack of standardized protocols and environmental conditions in laboratories made it difficult to replicate studies across different institutions. 4. **High workload with standard behavioral phenotyping**: The increasing number of mouse models and the complexity of manual testing methods led to significant time and resource constraints. IntelliCage was designed to address these issues by providing a user-friendly, automated system that can run without human supervision for extended periods. The system includes features such as RFID identification, reward delivery, and punishment stimuli, allowing for precise control over the testing environment. Early validation studies demonstrated the system's ability to detect subtle behavioral changes and transgenerational effects, even in noisy and uncontrollable environments. The IntelliCage has been widely adopted in various fields of behavioral neuroscience, including genetic modeling, impulsivity testing, and spatial learning. Its flexibility and versatility have allowed for sophisticated analysis of spontaneous behavior and hypothesis testing. Future developments aim to enhance stimulus presentation and social interaction tracking within the IntelliCage, further improving its utility in research. **Keywords:** home-cage testing, animal welfare, automated behavioral analysis, standardization, ethology and ecology, comparative and evolutionary neuroscience, marmoset (*Callithrix jacchus*), reproducibility.**IntelliCage: The Development and Perspectives of a Mouse- and User-Friendly Automated Behavioral Test System** The IntelliCage is a home-cage system designed to automate behavioral testing in mice, addressing issues of animal welfare, standardization, reproducibility, and the high workload associated with manual behavioral phenotyping. The system integrates four operant conditioning boxes into the corners of a standard mouse cage, allowing for individual identification and recording of mouse activity using subcutaneously implanted transponders. This setup enables the application of reward and punishment schemes in a social context, reducing handling stress and improving the realism of the testing environment. The development of IntelliCage was driven by four main factors: 1. **Dissatisfaction with standard phenotyping approaches**: Traditional behavioral tests often failed to provide standardized and reproducible results, leading to concerns about the reliability of findings. 2. **Animal welfare**: Standard tests, such as the water maze and shock-induced fear conditioning, were stressful for mice and required frequent handling, which can negatively impact their behavior. 3. **Standardization and reproducibility problems**: The lack of standardized protocols and environmental conditions in laboratories made it difficult to replicate studies across different institutions. 4. **High workload with standard behavioral phenotyping**: The increasing number of mouse models and the complexity of manual testing methods led to significant time and resource constraints. IntelliCage was designed to address these issues by providing a user-friendly, automated system that can run without human supervision for extended periods. The system includes features such as RFID identification, reward delivery, and punishment stimuli, allowing for precise control over the testing environment. Early validation studies demonstrated the system's ability to detect subtle behavioral changes and transgenerational effects, even in noisy and uncontrollable environments. The IntelliCage has been widely adopted in various fields of behavioral neuroscience, including genetic modeling, impulsivity testing, and spatial learning. Its flexibility and versatility have allowed for sophisticated analysis of spontaneous behavior and hypothesis testing. Future developments aim to enhance stimulus presentation and social interaction tracking within the IntelliCage, further improving its utility in research. **Keywords:** home-cage testing, animal welfare, automated behavioral analysis, standardization, ethology and ecology, comparative and evolutionary neuroscience, marmoset (*Callithrix jacchus*), reproducibility.