Mammals respond differently to changes in human activity, depending on their trophic group and landscape. During the COVID-19 pandemic, researchers used camera trapping to study how 163 mammal species responded to changes in human activity. They found that in more developed areas, mammals were more active, while in less developed areas, they were less active. Carnivores were the most sensitive, showing the greatest decrease in activity and increase in nocturnality. The study highlights the importance of considering species' traits and landscape characteristics when managing human-wildlife interactions. The results suggest that wildlife managers should consider the impact of human activity on different species and landscapes, especially in areas with high human modification. The study also emphasizes the need for further research on how mammal responses vary across different contexts and species. The findings have implications for conservation and management strategies in the Anthropocene.Mammals respond differently to changes in human activity, depending on their trophic group and landscape. During the COVID-19 pandemic, researchers used camera trapping to study how 163 mammal species responded to changes in human activity. They found that in more developed areas, mammals were more active, while in less developed areas, they were less active. Carnivores were the most sensitive, showing the greatest decrease in activity and increase in nocturnality. The study highlights the importance of considering species' traits and landscape characteristics when managing human-wildlife interactions. The results suggest that wildlife managers should consider the impact of human activity on different species and landscapes, especially in areas with high human modification. The study also emphasizes the need for further research on how mammal responses vary across different contexts and species. The findings have implications for conservation and management strategies in the Anthropocene.