This study addresses the multifaceted challenges of intervertebral disc degeneration (IVDD), a condition characterized by excessive reactive oxygen species (ROS) accumulation, cellular pyroptosis, and extracellular matrix (ECM) degradation. To combat these issues, the authors developed a novel multifunctional and microenvironment-responsive metal-phenolic network release platform, named TMP@Alg-PBA/PVA. This platform effectively scavenes ROS, suppresses pyroptosis, and promotes ECM regeneration. The metal-phenolic network (TA-Mn-PVP, or TMP) is released from the platform and targets mitochondria to efficiently scavenge ROS and reduce ECM degradation. Pyroptosis is inhibited through the inhibition of the IL-17/ERK signaling pathway. In a rat model of IVDD, the TMP@Alg-PBA/PVA platform demonstrated excellent therapeutic effects by reducing disease progression. The study's key findings include: 1. **ROS Scavenging and Pyroptosis Suppression**: TMP NPs effectively scavened ROS and inhibited pyroptosis, reducing the risk of IVDD. 2. **ECM Regeneration**: The platform promoted ECM regeneration, which is crucial for disc repair. 3. **Microenvironmental Response**: The hydrogel platform exhibited ROS-responsive degradability, ensuring targeted drug delivery to degenerated areas. 4. **Clinical Potential**: The TMP@Alg-PBA/PVA platform shows promise for the clinical treatment of IVDD, offering a synergistic approach to managing the disease. The research provides a comprehensive understanding of the mechanisms and therapeutic potential of the TMP@Alg-PBA/PVA platform, highlighting its effectiveness in treating IVDD through ROS scavenging, pyroptosis suppression, and ECM regeneration.This study addresses the multifaceted challenges of intervertebral disc degeneration (IVDD), a condition characterized by excessive reactive oxygen species (ROS) accumulation, cellular pyroptosis, and extracellular matrix (ECM) degradation. To combat these issues, the authors developed a novel multifunctional and microenvironment-responsive metal-phenolic network release platform, named TMP@Alg-PBA/PVA. This platform effectively scavenes ROS, suppresses pyroptosis, and promotes ECM regeneration. The metal-phenolic network (TA-Mn-PVP, or TMP) is released from the platform and targets mitochondria to efficiently scavenge ROS and reduce ECM degradation. Pyroptosis is inhibited through the inhibition of the IL-17/ERK signaling pathway. In a rat model of IVDD, the TMP@Alg-PBA/PVA platform demonstrated excellent therapeutic effects by reducing disease progression. The study's key findings include: 1. **ROS Scavenging and Pyroptosis Suppression**: TMP NPs effectively scavened ROS and inhibited pyroptosis, reducing the risk of IVDD. 2. **ECM Regeneration**: The platform promoted ECM regeneration, which is crucial for disc repair. 3. **Microenvironmental Response**: The hydrogel platform exhibited ROS-responsive degradability, ensuring targeted drug delivery to degenerated areas. 4. **Clinical Potential**: The TMP@Alg-PBA/PVA platform shows promise for the clinical treatment of IVDD, offering a synergistic approach to managing the disease. The research provides a comprehensive understanding of the mechanisms and therapeutic potential of the TMP@Alg-PBA/PVA platform, highlighting its effectiveness in treating IVDD through ROS scavenging, pyroptosis suppression, and ECM regeneration.