This paper presents a novel multi-criteria decision support framework for evaluating building thermal comfort in European buildings under climate change scenarios. The framework considers various comfort categories, building operation modes, and climate change sensitivity. It is applied to a high-performance timber dwelling near Brussels as a case study. The analysis shows an increase in indoor overheating by 1.7°C and ambient warmness by 6.5°C during heat waves from the current scenario to the end of the century. However, the reference timber dwelling effectively mitigates climate change impacts, particularly towards the end of the century. The framework supports decision-makers in evaluating building performance during the early design stages. The study highlights the need for further research on building performance assessment techniques and guidelines in a changing climate. The framework integrates international standards and state-of-the-art literature to provide a universal comparison of comfort models, key performance indicators (KPIs), and thresholds. It covers residential and commercial buildings, regardless of their age or type. The framework includes a multizonal, time-integrated, and climate change-sensitive method to evaluate overheating risks for future climate scenarios. The framework uses KPIs such as indoor overheating degree, ambient warmness degree, climate change overheating resistivity, hours of exceedance, and standard effective temperature. The study found that the reference dwelling's indoor operative temperature increased significantly during heat waves, with the highest temperature reaching 47°C. The framework is recommended for use in future building design to improve thermal comfort in a changing climate. The study also suggests that active and passive strategies should be used to mitigate overheating risks in the reference dwelling. The framework is expected to support decision-makers in evaluating building performance and mitigating climate change impacts on thermal comfort.This paper presents a novel multi-criteria decision support framework for evaluating building thermal comfort in European buildings under climate change scenarios. The framework considers various comfort categories, building operation modes, and climate change sensitivity. It is applied to a high-performance timber dwelling near Brussels as a case study. The analysis shows an increase in indoor overheating by 1.7°C and ambient warmness by 6.5°C during heat waves from the current scenario to the end of the century. However, the reference timber dwelling effectively mitigates climate change impacts, particularly towards the end of the century. The framework supports decision-makers in evaluating building performance during the early design stages. The study highlights the need for further research on building performance assessment techniques and guidelines in a changing climate. The framework integrates international standards and state-of-the-art literature to provide a universal comparison of comfort models, key performance indicators (KPIs), and thresholds. It covers residential and commercial buildings, regardless of their age or type. The framework includes a multizonal, time-integrated, and climate change-sensitive method to evaluate overheating risks for future climate scenarios. The framework uses KPIs such as indoor overheating degree, ambient warmness degree, climate change overheating resistivity, hours of exceedance, and standard effective temperature. The study found that the reference dwelling's indoor operative temperature increased significantly during heat waves, with the highest temperature reaching 47°C. The framework is recommended for use in future building design to improve thermal comfort in a changing climate. The study also suggests that active and passive strategies should be used to mitigate overheating risks in the reference dwelling. The framework is expected to support decision-makers in evaluating building performance and mitigating climate change impacts on thermal comfort.