This study aims to explore salivary biomarkers for the early detection of oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs). A scoping review was conducted using databases such as EBSCO, PubMed, Scopus, and Web of Science. Sixty-two studies were included, assessing over 100 molecules. The most studied markers were TNF-α, IL-1β, IL-6, IL-8, LDH, and MMP-9, with high sensitivity and specificity values. These biomarkers are promising but require larger cohort studies to validate their clinical utility. The review highlights the potential of salivary biomarkers in oral cancer diagnosis and management, emphasizing the need for further research to develop a panel of biomarkers for better accuracy.This study aims to explore salivary biomarkers for the early detection of oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs). A scoping review was conducted using databases such as EBSCO, PubMed, Scopus, and Web of Science. Sixty-two studies were included, assessing over 100 molecules. The most studied markers were TNF-α, IL-1β, IL-6, IL-8, LDH, and MMP-9, with high sensitivity and specificity values. These biomarkers are promising but require larger cohort studies to validate their clinical utility. The review highlights the potential of salivary biomarkers in oral cancer diagnosis and management, emphasizing the need for further research to develop a panel of biomarkers for better accuracy.