Clinical simulation has emerged as a crucial tool in the training of healthcare professionals, providing students with practical experiences in controlled environments. This study conducts a comprehensive systematic literature review to analyze its role and effectiveness. Simulation encompasses various modalities, from actors for communication skills to models for technical skills, offering a safe environment for practice and contributing to active learning and the development of essential competencies for health-focused careers. The results reveal compelling effectiveness, particularly in improving students' problem-solving skills and patient safety. However, challenges such as high costs and technological requirements are also highlighted. The review of studies indicates a convergence in supporting the effectiveness of simulation, although economic and logistical challenges remain significant aspects to consider. The introduction emphasizes the crucial role of practical training in healthcare education, highlighting clinical simulation as a key tool for developing skills and competencies. The methodology involves a systematic review of scientific literature to obtain precise and reliable data on the implementation and effectiveness of clinical simulation in medical education. The results and discussion section reveals evidence of the efficacy and relevance of clinical simulation, noting its ability to create realistic scenarios, promote active participation, and facilitate reflection. The debriefing process is highlighted as an integral part of simulation, providing valuable opportunities for continuous learning and performance improvement. The discussion section aligns with the findings of various studies, which consistently demonstrate the effectiveness of simulation in developing a range of competencies. However, it also addresses the inherent limitations and challenges, such as high costs and logistical complexities, which must be carefully balanced to ensure effective and sustainable implementation. The conclusion underscores the essential role of clinical simulation in healthcare education, emphasizing the need to address its limitations to enhance its effectiveness and contribute to the preparation of future leaders in the field of health.Clinical simulation has emerged as a crucial tool in the training of healthcare professionals, providing students with practical experiences in controlled environments. This study conducts a comprehensive systematic literature review to analyze its role and effectiveness. Simulation encompasses various modalities, from actors for communication skills to models for technical skills, offering a safe environment for practice and contributing to active learning and the development of essential competencies for health-focused careers. The results reveal compelling effectiveness, particularly in improving students' problem-solving skills and patient safety. However, challenges such as high costs and technological requirements are also highlighted. The review of studies indicates a convergence in supporting the effectiveness of simulation, although economic and logistical challenges remain significant aspects to consider. The introduction emphasizes the crucial role of practical training in healthcare education, highlighting clinical simulation as a key tool for developing skills and competencies. The methodology involves a systematic review of scientific literature to obtain precise and reliable data on the implementation and effectiveness of clinical simulation in medical education. The results and discussion section reveals evidence of the efficacy and relevance of clinical simulation, noting its ability to create realistic scenarios, promote active participation, and facilitate reflection. The debriefing process is highlighted as an integral part of simulation, providing valuable opportunities for continuous learning and performance improvement. The discussion section aligns with the findings of various studies, which consistently demonstrate the effectiveness of simulation in developing a range of competencies. However, it also addresses the inherent limitations and challenges, such as high costs and logistical complexities, which must be carefully balanced to ensure effective and sustainable implementation. The conclusion underscores the essential role of clinical simulation in healthcare education, emphasizing the need to address its limitations to enhance its effectiveness and contribute to the preparation of future leaders in the field of health.