Stachytarpheta jamaicensis tea significantly alters plasma lipid profiles and atherogenic indices in rabbits. The study investigated the effects of daily administration of 15mg/kg of aqueous extract of the tea on plasma lipid levels and atherogenic indices. The results showed significant decreases in total, LDL-, and VLDL-cholesterol, and triglycerides, along with a significant increase in HDL cholesterol levels. These changes led to significant reductions in atherogenic indices, including the cardiac risk ratio, atherogenic coefficient, and atherogenic index of plasma. These findings suggest that Stachytarpheta jamaicensis tea may be beneficial in managing dyslipidemia, which is a risk factor for cardiovascular diseases and commonly associated with diabetes mellitus and hypertension. The tea's potential therapeutic effects may be attributed to its phytochemical constituents, including flavonoids, triterpenes, monoterpenes, iridoids, phytosterols, and aromatic acids. The study highlights the potential of Stachytarpheta jamaicensis as a natural remedy for lipid-related disorders, particularly in the context of hypertension, where conventional diuretics may exacerbate hyperlipidemia. The results indicate that the tea may offer a protective effect against atherosclerosis and coronary heart disease by improving lipid profiles and reducing atherogenic risk factors. The study underscores the importance of further research to validate these findings in human populations.Stachytarpheta jamaicensis tea significantly alters plasma lipid profiles and atherogenic indices in rabbits. The study investigated the effects of daily administration of 15mg/kg of aqueous extract of the tea on plasma lipid levels and atherogenic indices. The results showed significant decreases in total, LDL-, and VLDL-cholesterol, and triglycerides, along with a significant increase in HDL cholesterol levels. These changes led to significant reductions in atherogenic indices, including the cardiac risk ratio, atherogenic coefficient, and atherogenic index of plasma. These findings suggest that Stachytarpheta jamaicensis tea may be beneficial in managing dyslipidemia, which is a risk factor for cardiovascular diseases and commonly associated with diabetes mellitus and hypertension. The tea's potential therapeutic effects may be attributed to its phytochemical constituents, including flavonoids, triterpenes, monoterpenes, iridoids, phytosterols, and aromatic acids. The study highlights the potential of Stachytarpheta jamaicensis as a natural remedy for lipid-related disorders, particularly in the context of hypertension, where conventional diuretics may exacerbate hyperlipidemia. The results indicate that the tea may offer a protective effect against atherosclerosis and coronary heart disease by improving lipid profiles and reducing atherogenic risk factors. The study underscores the importance of further research to validate these findings in human populations.