This review explores the potential of exosomes in treating skeletal muscle diseases, a broad category of conditions that include acute muscle injuries and muscular dystrophies. Exosomes, small extracellular vesicles (30-150 nm) containing proteins, nucleic acids, and lipids, play a crucial role in cellular communication and signaling. They are involved in various physiological and pathological processes, including muscle repair, regeneration, and immune regulation. The review highlights the mechanisms by which exosomes influence muscle cell proliferation, differentiation, and migration, as well as their ability to modulate inflammation and promote angiogenesis. Exosomes have shown promise in treating skeletal muscle injuries, sarcopenia, and atrophy, offering innovative therapeutic strategies. However, challenges such as the lack of uniform extraction and purification methods and the need for further research on their complex mechanisms remain. Despite these obstacles, exosomes hold significant potential for advancing regenerative medicine and improving the quality of life for individuals with skeletal muscle disorders.This review explores the potential of exosomes in treating skeletal muscle diseases, a broad category of conditions that include acute muscle injuries and muscular dystrophies. Exosomes, small extracellular vesicles (30-150 nm) containing proteins, nucleic acids, and lipids, play a crucial role in cellular communication and signaling. They are involved in various physiological and pathological processes, including muscle repair, regeneration, and immune regulation. The review highlights the mechanisms by which exosomes influence muscle cell proliferation, differentiation, and migration, as well as their ability to modulate inflammation and promote angiogenesis. Exosomes have shown promise in treating skeletal muscle injuries, sarcopenia, and atrophy, offering innovative therapeutic strategies. However, challenges such as the lack of uniform extraction and purification methods and the need for further research on their complex mechanisms remain. Despite these obstacles, exosomes hold significant potential for advancing regenerative medicine and improving the quality of life for individuals with skeletal muscle disorders.