This study evaluated the prognostic value of eight cellular and serologic markers in HIV-1 infection to predict the progression to clinical AIDS. The cellular markers included CD4+ T cell count, CD8+ T cell count, and the CD4+/CD8+ ratio. The serologic markers were neopterin, beta2-microglobulin, soluble interleukin-2 receptors, IgA, and HIV p24 antigen. The study followed 395 HIV-seropositive homosexual men initially free of AIDS for four years. CD4+ T cell count was the best single predictor of AIDS progression, but neopterin and beta2-microglobulin levels also showed significant predictive power. The combination of CD4+ T cell count and neopterin level had the highest prognostic value. Multivariate analyses indicated that the CD4+/CD8+ ratio, neopterin level, IgA level, and p24 antigen level were the best predictors of AIDS progression. These findings highlight the importance of both immune deficits and immune stimulation in predicting AIDS progression, with neopterin and beta2-microglobulin levels reflecting immune stimulation being particularly significant. The study suggests that these markers could be valuable in evaluating antiviral therapy and managing HIV infection and AIDS.This study evaluated the prognostic value of eight cellular and serologic markers in HIV-1 infection to predict the progression to clinical AIDS. The cellular markers included CD4+ T cell count, CD8+ T cell count, and the CD4+/CD8+ ratio. The serologic markers were neopterin, beta2-microglobulin, soluble interleukin-2 receptors, IgA, and HIV p24 antigen. The study followed 395 HIV-seropositive homosexual men initially free of AIDS for four years. CD4+ T cell count was the best single predictor of AIDS progression, but neopterin and beta2-microglobulin levels also showed significant predictive power. The combination of CD4+ T cell count and neopterin level had the highest prognostic value. Multivariate analyses indicated that the CD4+/CD8+ ratio, neopterin level, IgA level, and p24 antigen level were the best predictors of AIDS progression. These findings highlight the importance of both immune deficits and immune stimulation in predicting AIDS progression, with neopterin and beta2-microglobulin levels reflecting immune stimulation being particularly significant. The study suggests that these markers could be valuable in evaluating antiviral therapy and managing HIV infection and AIDS.