The paper presents a method for creating three-dimensional (3D) nanoarchitectures of inorganic materials using DNA-programmable assembly and templating. By synthesizing DNA origami frameworks, the researchers developed a general approach to fabricate ordered 3D inorganic structures. Through liquid- and vapor-phase infiltration, they successfully fabricated diverse inorganic frameworks from metals, metal oxides, and semiconductors, including zinc, aluminum, copper, molybdenum, tungsten, indium, tin, and platinum, as well as composites like aluminum-doped zinc oxide, indium tin oxide, and platinum/aluminum-doped zinc oxide. The 3D frameworks exhibit nanoscale features with architectures prescribed by the DNA frames and self-assembled lattice. Structural and spectroscopic studies revealed the composition and organization of the inorganic frameworks, as well as their optoelectronic properties. This work paves the way for 3D nanoscale lithography and the development of complex 3D nanostructures with tailored functionalities.The paper presents a method for creating three-dimensional (3D) nanoarchitectures of inorganic materials using DNA-programmable assembly and templating. By synthesizing DNA origami frameworks, the researchers developed a general approach to fabricate ordered 3D inorganic structures. Through liquid- and vapor-phase infiltration, they successfully fabricated diverse inorganic frameworks from metals, metal oxides, and semiconductors, including zinc, aluminum, copper, molybdenum, tungsten, indium, tin, and platinum, as well as composites like aluminum-doped zinc oxide, indium tin oxide, and platinum/aluminum-doped zinc oxide. The 3D frameworks exhibit nanoscale features with architectures prescribed by the DNA frames and self-assembled lattice. Structural and spectroscopic studies revealed the composition and organization of the inorganic frameworks, as well as their optoelectronic properties. This work paves the way for 3D nanoscale lithography and the development of complex 3D nanostructures with tailored functionalities.