This study presents a novel design strategy, the Gradient Stiffness Sliding (GSS) method, to create ultra-sensitive, highly linear, and hysteresis-free strain sensors. The GSS method involves controlling the distribution of the locally enhanced electric field and the heterogeneous deformation of the substrate to significantly improve sensitivity while maintaining high linearity. The resulting strain sensor exhibits a giant gauge factor (9.1 × 10^9) and linearity (R^2 = 0.9997) over the entire sensing range, with almost no hysteresis and a fast response time (17 ms). The GSS method is expected to be applicable to other types of sensors to achieve ultra-high sensitivity and linearity simultaneously. The sensor's performance is validated through various tests, including mechanical finite-element analysis, electrical finite-element analysis, and practical applications such as monitoring human signals and everyday activities. The GSS-designed sensor demonstrates superior sensitivity, linearity, and stability, making it a promising candidate for wearable sensing systems and flexible electronics.This study presents a novel design strategy, the Gradient Stiffness Sliding (GSS) method, to create ultra-sensitive, highly linear, and hysteresis-free strain sensors. The GSS method involves controlling the distribution of the locally enhanced electric field and the heterogeneous deformation of the substrate to significantly improve sensitivity while maintaining high linearity. The resulting strain sensor exhibits a giant gauge factor (9.1 × 10^9) and linearity (R^2 = 0.9997) over the entire sensing range, with almost no hysteresis and a fast response time (17 ms). The GSS method is expected to be applicable to other types of sensors to achieve ultra-high sensitivity and linearity simultaneously. The sensor's performance is validated through various tests, including mechanical finite-element analysis, electrical finite-element analysis, and practical applications such as monitoring human signals and everyday activities. The GSS-designed sensor demonstrates superior sensitivity, linearity, and stability, making it a promising candidate for wearable sensing systems and flexible electronics.