This study investigates the factors influencing the adoption of digital health solutions in general practices through a mixed-methods approach. The research identifies moderate overall barriers, including required workflow adjustments, inadequate reimbursement, and high training effort. Improvement strategies, such as improved interoperability, continued technical support, and enhanced usability, are considered important. The study finds that practice-related characteristics, future digital health usage, GPs' digital affinity, personality traits, and digital maturity significantly predict the perceived strength of barriers. For the perceived importance of improvement strategies, only demographics and usage-related variables are significant predictors. The findings highlight the need for comprehensive approaches that integrate personal and emotional elements to make digitization more engaging and applicable in general practices. The study provides evidence for the impact of GPs' inherent characteristics on barriers and improvement strategies, emphasizing the importance of addressing these factors to facilitate the successful integration of digital health solutions.This study investigates the factors influencing the adoption of digital health solutions in general practices through a mixed-methods approach. The research identifies moderate overall barriers, including required workflow adjustments, inadequate reimbursement, and high training effort. Improvement strategies, such as improved interoperability, continued technical support, and enhanced usability, are considered important. The study finds that practice-related characteristics, future digital health usage, GPs' digital affinity, personality traits, and digital maturity significantly predict the perceived strength of barriers. For the perceived importance of improvement strategies, only demographics and usage-related variables are significant predictors. The findings highlight the need for comprehensive approaches that integrate personal and emotional elements to make digitization more engaging and applicable in general practices. The study provides evidence for the impact of GPs' inherent characteristics on barriers and improvement strategies, emphasizing the importance of addressing these factors to facilitate the successful integration of digital health solutions.