This study introduces a novel ionic conductive hydrogel (ULAS) system using an imidazolium salt with a ureido backbone (UL) as the primary monomer, fabricated through a one-pot copolymerization process involving betaine sulfonate methacrylate (SBMA) and acrylamide (AM). The ULAS hydrogel exhibits superior mechanical properties, strain responsiveness, water retention, self-healing capabilities, and advanced self-regenerative and healing abilities. It also shows broad-spectrum antibacterial activity and is suitable for biomechanical monitoring, particularly in contact and noncontact electrocardiogram (ECG) devices. The conductive properties of the hydrogel make it ideal for electrophoretic patches used in treating infected wounds. The study highlights the potential of ULAS hydrogels in various applications, including cardiac surveillance and wound healing, due to their unique combination of desirable attributes.This study introduces a novel ionic conductive hydrogel (ULAS) system using an imidazolium salt with a ureido backbone (UL) as the primary monomer, fabricated through a one-pot copolymerization process involving betaine sulfonate methacrylate (SBMA) and acrylamide (AM). The ULAS hydrogel exhibits superior mechanical properties, strain responsiveness, water retention, self-healing capabilities, and advanced self-regenerative and healing abilities. It also shows broad-spectrum antibacterial activity and is suitable for biomechanical monitoring, particularly in contact and noncontact electrocardiogram (ECG) devices. The conductive properties of the hydrogel make it ideal for electrophoretic patches used in treating infected wounds. The study highlights the potential of ULAS hydrogels in various applications, including cardiac surveillance and wound healing, due to their unique combination of desirable attributes.