The article reviews the use of white rot fungi (WRF) in bioremediation to address the issue of xenobiotic chemical pollution in soil and water. WRF are unique microorganisms capable of degrading a wide range of toxic xenobiotic compounds, including synthetic dyes, chlorophenols, polychlorinated biphenyls, organophosphate pesticides, explosives, and polycyclic aromatic hydrocarbons (PAHs). The review covers the main classes of enzymes involved in fungal degradation, such as laccases, class II heme-containing peroxidases (lignin peroxidases, manganese peroxidases, versatile peroxidases), aryl alcohol oxidases, glyoxal oxidases, dye-decolorizing peroxidases, and cytochrome P450 monooxygenases. It also discusses the mechanisms used by fungi to degrade these chemicals, including biosorption, biodegradation, and enzymatic mineralization. The suitability of fungal biomass or extracellular enzymes for bioremediation is explored, along with the application of WRF in degrading pollutants like synthetic dyes, PAHs, and emerging pollutants such as pharmaceuticals and perfluoroalkyl/polyfluoroalkyl substances (PFASs). Finally, the article addresses the current limitations of using WRF for bioremediation and future strategies to improve biodegradation processes.The article reviews the use of white rot fungi (WRF) in bioremediation to address the issue of xenobiotic chemical pollution in soil and water. WRF are unique microorganisms capable of degrading a wide range of toxic xenobiotic compounds, including synthetic dyes, chlorophenols, polychlorinated biphenyls, organophosphate pesticides, explosives, and polycyclic aromatic hydrocarbons (PAHs). The review covers the main classes of enzymes involved in fungal degradation, such as laccases, class II heme-containing peroxidases (lignin peroxidases, manganese peroxidases, versatile peroxidases), aryl alcohol oxidases, glyoxal oxidases, dye-decolorizing peroxidases, and cytochrome P450 monooxygenases. It also discusses the mechanisms used by fungi to degrade these chemicals, including biosorption, biodegradation, and enzymatic mineralization. The suitability of fungal biomass or extracellular enzymes for bioremediation is explored, along with the application of WRF in degrading pollutants like synthetic dyes, PAHs, and emerging pollutants such as pharmaceuticals and perfluoroalkyl/polyfluoroalkyl substances (PFASs). Finally, the article addresses the current limitations of using WRF for bioremediation and future strategies to improve biodegradation processes.