The chapter discusses the development of "giant" multishell CdSe nanocrystal quantum dots (QDs) that exhibit suppressed blinking. The research, conducted by Yongfen Chen, Javier Vela, Han Htoon, Joanna L. Casson, Donald J. Werder, David A. Bussian, Victor I. Klimov, and Jennifer A. Hollingsworth from Los Alamos National Laboratory, was presented at the 236th American Chemical Society National Meeting in Philadelphia, PA, in 2008. The study focuses on the fluorescence intermittency of single CdSe QDs, including photostability and dynamic light scattering analysis of the g-NQDs. The research was supported by LANL LDRD and the DOE Center for Integrated Nanotechnologies.The chapter discusses the development of "giant" multishell CdSe nanocrystal quantum dots (QDs) that exhibit suppressed blinking. The research, conducted by Yongfen Chen, Javier Vela, Han Htoon, Joanna L. Casson, Donald J. Werder, David A. Bussian, Victor I. Klimov, and Jennifer A. Hollingsworth from Los Alamos National Laboratory, was presented at the 236th American Chemical Society National Meeting in Philadelphia, PA, in 2008. The study focuses on the fluorescence intermittency of single CdSe QDs, including photostability and dynamic light scattering analysis of the g-NQDs. The research was supported by LANL LDRD and the DOE Center for Integrated Nanotechnologies.