This case report presents a 41-year-old woman with Takayasu arteritis (T.A.) involving the right subclavian artery occlusion and right common iliac artery stenosis, with rapid disease progression leading to left subclavian artery occlusion and distal aortic stenosis within six months. The most rational diagnostic and therapeutic approach was implemented. Key terms: Takayasu arteritis - diagnosis + therapy - etiology + epidemiology + surgery. Takayasu arteritis is a vasculitis affecting the aorta and its major branches. It predominantly involves the aortic arch and its main branches, including the brachiocephalic trunk, subclavian, and carotid arteries. The disease can affect any part of the aorta or its direct branches. It is also known as aortitis syndrome, aortic arch syndrome, reverse coarctation of the aorta, pulseless disease, brachiocephalic arteritis, and occlusive aortopaties. According to Faucius' classification, aortitis syndrome along with temporal arteritis belongs to the group of granulomatous arteritis. Inflammation, degeneration, and sclerosis of the arterial wall lead to luminal narrowing and subsequent occlusion with thrombosis. Weakness of the inflamed wall can lead to aneurysm formation. The wide range of symptoms is due to ischemia from varying degrees of stenosis, occlusion, or dilation of the affected arterial segment. The type and size of the affected artery, the type and significance of the organs supplied, and the development of collateral circulation determine the symptoms. If multiple blood vessels are involved, the symptoms may be polymorphic. Four types of the disease are distinguished based on localization (Veno 1967, Lupi Herera 1977, etc.). Type I: affects the aortic arch and its branches. Type II: affects the thoracic and abdominal aorta without involvement of the aortic arch. Type III: mixed type. Type IV: in addition to the first three types, pulmonary arteries are affected. The disease has a pan-European character, with the highest incidence in the Far East. The incidence of Takayasu disease in whites is about 2.6 per 100,000 people per year. Women are more commonly affected, around 80%. The etiology is unknown, and the pathogenesis is unclear. Possible causes include infections such as tuberculosis, streptococci, and viruses, but there is no clear evidence of their association with the disease. There is a pathohistological similarity between changes in the affected blood vessel and tuberculosis, but without caseous necrosis. During rheumatic fever, changes may occur in the aorta. Sowdring and Welin found that 75% of 20 patients with rheumatic fever later developed TakThis case report presents a 41-year-old woman with Takayasu arteritis (T.A.) involving the right subclavian artery occlusion and right common iliac artery stenosis, with rapid disease progression leading to left subclavian artery occlusion and distal aortic stenosis within six months. The most rational diagnostic and therapeutic approach was implemented. Key terms: Takayasu arteritis - diagnosis + therapy - etiology + epidemiology + surgery. Takayasu arteritis is a vasculitis affecting the aorta and its major branches. It predominantly involves the aortic arch and its main branches, including the brachiocephalic trunk, subclavian, and carotid arteries. The disease can affect any part of the aorta or its direct branches. It is also known as aortitis syndrome, aortic arch syndrome, reverse coarctation of the aorta, pulseless disease, brachiocephalic arteritis, and occlusive aortopaties. According to Faucius' classification, aortitis syndrome along with temporal arteritis belongs to the group of granulomatous arteritis. Inflammation, degeneration, and sclerosis of the arterial wall lead to luminal narrowing and subsequent occlusion with thrombosis. Weakness of the inflamed wall can lead to aneurysm formation. The wide range of symptoms is due to ischemia from varying degrees of stenosis, occlusion, or dilation of the affected arterial segment. The type and size of the affected artery, the type and significance of the organs supplied, and the development of collateral circulation determine the symptoms. If multiple blood vessels are involved, the symptoms may be polymorphic. Four types of the disease are distinguished based on localization (Veno 1967, Lupi Herera 1977, etc.). Type I: affects the aortic arch and its branches. Type II: affects the thoracic and abdominal aorta without involvement of the aortic arch. Type III: mixed type. Type IV: in addition to the first three types, pulmonary arteries are affected. The disease has a pan-European character, with the highest incidence in the Far East. The incidence of Takayasu disease in whites is about 2.6 per 100,000 people per year. Women are more commonly affected, around 80%. The etiology is unknown, and the pathogenesis is unclear. Possible causes include infections such as tuberculosis, streptococci, and viruses, but there is no clear evidence of their association with the disease. There is a pathohistological similarity between changes in the affected blood vessel and tuberculosis, but without caseous necrosis. During rheumatic fever, changes may occur in the aorta. Sowdring and Welin found that 75% of 20 patients with rheumatic fever later developed Tak