A randomized controlled study compared the efficacy of nebulization therapy with cefmenoxime (CMX) and steroid to oral resolutional enzyme therapy for chronic sinusitis. The study involved 18 patients in the nebulization group and 15 in the oral enzyme group. Clinical efficacy was 77.8% in the nebulization group and 26.7% in the oral enzyme group, with a statistically significant difference (p < 0.01). Nebulization therapy, which delivers medication directly to the nasal passages and sinuses, was found to be more effective than oral enzyme therapy. The study highlights the potential benefits of nebulization therapy, including its safety, convenience, and ability to target the affected areas directly. The results suggest that nebulization therapy with CMX and steroid is more effective than oral resolutional enzymes for chronic sinusitis. The study also emphasizes the importance of proper patient selection and monitoring to ensure safe and effective treatment. The findings support the use of nebulization therapy as a preferred treatment option for chronic sinusitis.A randomized controlled study compared the efficacy of nebulization therapy with cefmenoxime (CMX) and steroid to oral resolutional enzyme therapy for chronic sinusitis. The study involved 18 patients in the nebulization group and 15 in the oral enzyme group. Clinical efficacy was 77.8% in the nebulization group and 26.7% in the oral enzyme group, with a statistically significant difference (p < 0.01). Nebulization therapy, which delivers medication directly to the nasal passages and sinuses, was found to be more effective than oral enzyme therapy. The study highlights the potential benefits of nebulization therapy, including its safety, convenience, and ability to target the affected areas directly. The results suggest that nebulization therapy with CMX and steroid is more effective than oral resolutional enzymes for chronic sinusitis. The study also emphasizes the importance of proper patient selection and monitoring to ensure safe and effective treatment. The findings support the use of nebulization therapy as a preferred treatment option for chronic sinusitis.