The article discusses the application of 3D printing (3DP) technology in the pharmaceutical industry, particularly in the development of personalized drug delivery systems. 3DP technology, also known as additive manufacturing, allows for the creation of complex drug combinations, personalized dosages, and flexible shapes and structures of dosage forms (DFs) on demand. The authors review various 3DP techniques, including material extrusion, vat photopolymerization, powder bed fusion, and jet printing, detailing their processes and advantages. They highlight the potential of 3DP in producing immediate release (IR), delayed release (DR), sustained release (SR), and pulsatile release (PR) DFs. The article also explores the use of 3DP in creating personalized combination and polypill formulations and microneedles. Examples of successful 3DP-based DFs are provided, such as levetiracetam tablets for epilepsy, oral disintegrating tablets for children, and colon-targeted oxaliplatin sheets for cancer treatment. The authors discuss the benefits, challenges, and future prospects of 3DP technology in the pharmaceutical industry, emphasizing its role in enhancing patient compliance and improving drug efficacy and safety.The article discusses the application of 3D printing (3DP) technology in the pharmaceutical industry, particularly in the development of personalized drug delivery systems. 3DP technology, also known as additive manufacturing, allows for the creation of complex drug combinations, personalized dosages, and flexible shapes and structures of dosage forms (DFs) on demand. The authors review various 3DP techniques, including material extrusion, vat photopolymerization, powder bed fusion, and jet printing, detailing their processes and advantages. They highlight the potential of 3DP in producing immediate release (IR), delayed release (DR), sustained release (SR), and pulsatile release (PR) DFs. The article also explores the use of 3DP in creating personalized combination and polypill formulations and microneedles. Examples of successful 3DP-based DFs are provided, such as levetiracetam tablets for epilepsy, oral disintegrating tablets for children, and colon-targeted oxaliplatin sheets for cancer treatment. The authors discuss the benefits, challenges, and future prospects of 3DP technology in the pharmaceutical industry, emphasizing its role in enhancing patient compliance and improving drug efficacy and safety.