This study evaluates the effectiveness of ChatGPT 3.5 and 4.0 in translating 54 English kidney transplant FAQs into Spanish for the Hispanic community. The FAQs were sourced from three organizations: Organ Procurement and Transplantation Network (OPTN), National Health Service (NHS), and National Kidney Foundation (NKF). Two Spanish-speaking nephrologists, both of Mexican heritage, assessed the translations for linguistic accuracy and cultural sensitivity using a 1–5 rubric. The inter-rater reliability was 0.85, indicating high agreement. Both versions of ChatGPT achieved high scores in linguistic accuracy and cultural sensitivity, with ChatGPT 4.0 slightly outperforming 3.5 in accuracy. The results suggest that AI-driven translations can effectively bridge language barriers, improving access to essential kidney transplant information for Spanish-speaking Hispanics. The study highlights the potential of AI in promoting health equity by providing culturally sensitive and accurate translations. However, further research is needed to evaluate AI's capabilities across diverse contexts and languages. The findings indicate that AI can play a crucial role in reducing healthcare disparities by making medical information more accessible to non-English-speaking populations.This study evaluates the effectiveness of ChatGPT 3.5 and 4.0 in translating 54 English kidney transplant FAQs into Spanish for the Hispanic community. The FAQs were sourced from three organizations: Organ Procurement and Transplantation Network (OPTN), National Health Service (NHS), and National Kidney Foundation (NKF). Two Spanish-speaking nephrologists, both of Mexican heritage, assessed the translations for linguistic accuracy and cultural sensitivity using a 1–5 rubric. The inter-rater reliability was 0.85, indicating high agreement. Both versions of ChatGPT achieved high scores in linguistic accuracy and cultural sensitivity, with ChatGPT 4.0 slightly outperforming 3.5 in accuracy. The results suggest that AI-driven translations can effectively bridge language barriers, improving access to essential kidney transplant information for Spanish-speaking Hispanics. The study highlights the potential of AI in promoting health equity by providing culturally sensitive and accurate translations. However, further research is needed to evaluate AI's capabilities across diverse contexts and languages. The findings indicate that AI can play a crucial role in reducing healthcare disparities by making medical information more accessible to non-English-speaking populations.