AMIDE (Amide’s a Medical Image Data Examiner) is a user-friendly, open-source software tool designed for displaying and analyzing multimodality volumetric medical images. It supports multiple data sets (e.g., PET, CT, MRI) and regions of interest (ROIs) simultaneously, allowing for free shifts, rotations, and views with automatic interpolation. The software is validated against existing packages and runs on UNIX, Macintosh OS X, and Microsoft Windows, distributed under the GNU General Public License (GPL). Key features include three-dimensional ROI drawing, linked viewing, rigid body registration, filtering, cropping, movie generation, and volume rendering. AMIDE's unique design avoids complex user interfaces and handles data in real-world units, making it accessible to researchers with minimal imaging experience. The software is freely available for download, with source code and installation instructions provided on the AMIDE website.AMIDE (Amide’s a Medical Image Data Examiner) is a user-friendly, open-source software tool designed for displaying and analyzing multimodality volumetric medical images. It supports multiple data sets (e.g., PET, CT, MRI) and regions of interest (ROIs) simultaneously, allowing for free shifts, rotations, and views with automatic interpolation. The software is validated against existing packages and runs on UNIX, Macintosh OS X, and Microsoft Windows, distributed under the GNU General Public License (GPL). Key features include three-dimensional ROI drawing, linked viewing, rigid body registration, filtering, cropping, movie generation, and volume rendering. AMIDE's unique design avoids complex user interfaces and handles data in real-world units, making it accessible to researchers with minimal imaging experience. The software is freely available for download, with source code and installation instructions provided on the AMIDE website.