The chapter discusses the role of ATP-dependent chromatin remodeling complexes in various cellular processes, focusing on their genetics, genomics, and mechanisms. These complexes, which include the SWI/SNF, INO80, ISWI, and CHD families, are crucial for regulating gene expression, DNA repair, and cell cycle control. The SWI/SNF family, initially identified in yeast, has expanded in mammals to include multiple subunits, many of which are tumor suppressors. The INO80 family, characterized by a split ATPase domain, is involved in DNA repair and telomere maintenance. The ISWI family, with its DEAD/H-related ATPase, facilitates nucleosome remodeling and is essential for chromatin structure. The CHD family, while less well-studied, also plays a role in chromatin regulation. The chapter highlights the importance of subunit composition and the specialized functions of these complexes, as well as the role of associated proteins like actin and Arp proteins in their function. Recent genetic studies have revealed that mutations in these complexes are associated with cancer and developmental disorders, emphasizing their critical role in maintaining cellular homeostasis.The chapter discusses the role of ATP-dependent chromatin remodeling complexes in various cellular processes, focusing on their genetics, genomics, and mechanisms. These complexes, which include the SWI/SNF, INO80, ISWI, and CHD families, are crucial for regulating gene expression, DNA repair, and cell cycle control. The SWI/SNF family, initially identified in yeast, has expanded in mammals to include multiple subunits, many of which are tumor suppressors. The INO80 family, characterized by a split ATPase domain, is involved in DNA repair and telomere maintenance. The ISWI family, with its DEAD/H-related ATPase, facilitates nucleosome remodeling and is essential for chromatin structure. The CHD family, while less well-studied, also plays a role in chromatin regulation. The chapter highlights the importance of subunit composition and the specialized functions of these complexes, as well as the role of associated proteins like actin and Arp proteins in their function. Recent genetic studies have revealed that mutations in these complexes are associated with cancer and developmental disorders, emphasizing their critical role in maintaining cellular homeostasis.