This clinical commentary by Rachel K. Straub and Christopher M. Powers reviews the biomechanical demands of the squat exercise and its implications for clinical practice. The squat is a frequently prescribed exercise in rehabilitation and sports performance, targeting the lower extremity muscles, particularly the hip and knee extensors. The authors discuss how various parameters such as trunk inclination, tibia inclination, foot rotation, stance width, and depth can influence joint loading and muscular demands. They provide general recommendations for specific clinical conditions, including patellofemoral pain, post-ACL reconstruction, femoroacetabular impingement, and low back pain. The commentary emphasizes the importance of understanding the biomechanical interactions among these parameters to prescribe appropriate squatting techniques that maximize effectiveness and minimize risk. The authors conclude by highlighting the need for further research to establish the appropriateness and effectiveness of squat exercises for various musculoskeletal conditions.This clinical commentary by Rachel K. Straub and Christopher M. Powers reviews the biomechanical demands of the squat exercise and its implications for clinical practice. The squat is a frequently prescribed exercise in rehabilitation and sports performance, targeting the lower extremity muscles, particularly the hip and knee extensors. The authors discuss how various parameters such as trunk inclination, tibia inclination, foot rotation, stance width, and depth can influence joint loading and muscular demands. They provide general recommendations for specific clinical conditions, including patellofemoral pain, post-ACL reconstruction, femoroacetabular impingement, and low back pain. The commentary emphasizes the importance of understanding the biomechanical interactions among these parameters to prescribe appropriate squatting techniques that maximize effectiveness and minimize risk. The authors conclude by highlighting the need for further research to establish the appropriateness and effectiveness of squat exercises for various musculoskeletal conditions.