This comprehensive review explores the historical, current, and future prospects of telemedicine technologies. Telemedicine has evolved significantly, providing healthcare services and exchanging medical information remotely. The historical overview traces its roots from early experiments to its current state, marked by advanced technology, diverse applications, and increased adoption, especially during the COVID-19 pandemic. Emerging technologies like AI, VR, IoT, and blockchain promise to revolutionize telemedicine, enhancing diagnostics, patient monitoring, and personalized treatment. Potential applications range from chronic disease management to tele-ICUs and global health initiatives. To maximize telemedicine's benefits, healthcare providers, technology developers, policymakers, and researchers are offered recommendations. Telemedicine's potential to transform healthcare delivery is profound, fostering accessibility, efficiency, and improved patient outcomes. While challenges exist, addressing them will help create a future where telemedicine is central to delivering equitable and patient-centred healthcare. Telemedicine is a transformative force poised to redefine healthcare delivery, offering unparalleled opportunities to augment accessibility, efficiency, and patient outcomes. As telemedicine continues to evolve, it is essential to address ethical, legal, and social implications to ensure equitable access and patient safety. The future of telemedicine holds immense promise, driven by emerging technologies and evolving healthcare needs. Emerging technologies such as AI, VR, IoT, and blockchain are poised to revolutionize telemedicine, enhancing diagnostics, patient monitoring, and personalized treatment. Potential applications include chronic disease management, tele-ICUs, and global health initiatives. Predicted trends in adoption and utilization include hybrid care models, enhanced healthcare equity, and increased automation. The vision for the future is that telemedicine will be a fundamental component of healthcare ecosystems worldwide, providing seamless access to care across geographical boundaries and enabling precise, personalized, and proactive healthcare. However, achieving this vision requires ongoing collaboration between healthcare providers, technology innovators, policymakers, and patient advocates to address challenges and ensure equitable access. Ethical, legal, and social implications, including privacy and security, equity and access, and legal and regulatory considerations, must be carefully addressed to ensure the safe and effective use of telemedicine. The conclusion emphasizes the importance of harnessing the full potential of telemedicine to transform healthcare delivery for generations to come.This comprehensive review explores the historical, current, and future prospects of telemedicine technologies. Telemedicine has evolved significantly, providing healthcare services and exchanging medical information remotely. The historical overview traces its roots from early experiments to its current state, marked by advanced technology, diverse applications, and increased adoption, especially during the COVID-19 pandemic. Emerging technologies like AI, VR, IoT, and blockchain promise to revolutionize telemedicine, enhancing diagnostics, patient monitoring, and personalized treatment. Potential applications range from chronic disease management to tele-ICUs and global health initiatives. To maximize telemedicine's benefits, healthcare providers, technology developers, policymakers, and researchers are offered recommendations. Telemedicine's potential to transform healthcare delivery is profound, fostering accessibility, efficiency, and improved patient outcomes. While challenges exist, addressing them will help create a future where telemedicine is central to delivering equitable and patient-centred healthcare. Telemedicine is a transformative force poised to redefine healthcare delivery, offering unparalleled opportunities to augment accessibility, efficiency, and patient outcomes. As telemedicine continues to evolve, it is essential to address ethical, legal, and social implications to ensure equitable access and patient safety. The future of telemedicine holds immense promise, driven by emerging technologies and evolving healthcare needs. Emerging technologies such as AI, VR, IoT, and blockchain are poised to revolutionize telemedicine, enhancing diagnostics, patient monitoring, and personalized treatment. Potential applications include chronic disease management, tele-ICUs, and global health initiatives. Predicted trends in adoption and utilization include hybrid care models, enhanced healthcare equity, and increased automation. The vision for the future is that telemedicine will be a fundamental component of healthcare ecosystems worldwide, providing seamless access to care across geographical boundaries and enabling precise, personalized, and proactive healthcare. However, achieving this vision requires ongoing collaboration between healthcare providers, technology innovators, policymakers, and patient advocates to address challenges and ensure equitable access. Ethical, legal, and social implications, including privacy and security, equity and access, and legal and regulatory considerations, must be carefully addressed to ensure the safe and effective use of telemedicine. The conclusion emphasizes the importance of harnessing the full potential of telemedicine to transform healthcare delivery for generations to come.