11 January 2024 | R. Sowmya, S. Karthick Raja Namasivayam, S. Krithika Shree
This review provides a comprehensive overview of the principles and applications of nano-selenium-based materials, focusing on selenium nanoparticles (SeNPs) and selenium nanocomposites (SeNC). The study details various synthesis methods for nano-selenium, including physical, chemical, and biological approaches, and explores their potential biomedical uses such as antimicrobial, anticancer, anti-diabetic, and anti-oxidative activities. The toxicity of nano-selenium under in vitro and in vivo conditions is assessed using cost-effective and green technology principles, including cytotoxicity tests, phytotoxicity screening, and animal models like rats, mice, and zebrafish. The review highlights the enhanced biocompatibility and environmental friendliness of nano-selenium materials, making them promising for diverse applications. Selenium nanoparticles are noted for their lower toxicity compared to other forms of selenium and their therapeutic properties, particularly in targeted drug delivery and cancer treatment. The review also emphasizes the importance of selenium in human health and its role in various industrial and scientific fields.This review provides a comprehensive overview of the principles and applications of nano-selenium-based materials, focusing on selenium nanoparticles (SeNPs) and selenium nanocomposites (SeNC). The study details various synthesis methods for nano-selenium, including physical, chemical, and biological approaches, and explores their potential biomedical uses such as antimicrobial, anticancer, anti-diabetic, and anti-oxidative activities. The toxicity of nano-selenium under in vitro and in vivo conditions is assessed using cost-effective and green technology principles, including cytotoxicity tests, phytotoxicity screening, and animal models like rats, mice, and zebrafish. The review highlights the enhanced biocompatibility and environmental friendliness of nano-selenium materials, making them promising for diverse applications. Selenium nanoparticles are noted for their lower toxicity compared to other forms of selenium and their therapeutic properties, particularly in targeted drug delivery and cancer treatment. The review also emphasizes the importance of selenium in human health and its role in various industrial and scientific fields.