This chapter discusses a modified procedure for lead staining of thin tissue sections, addressing the issues of contamination and instability associated with traditional lead hydroxide solutions. The authors describe the limitations of existing methods, such as the instability of lead hydroxide in air and the difficulty in achieving uniform staining. They propose a new solution that combines sodium hydroxide and potassium sodium tartrate to stabilize the lead salt, preventing precipitation and maintaining clarity even when exposed to air. The modified solution is stable, effective, and does not damage the sections, making it suitable for electron microscopy. The authors provide detailed instructions for preparing and using the solution, including dilution and storage methods. Comparative studies show that the new staining method produces similar results to the original lead hydroxide solution, with the added benefit of reduced contamination and improved clarity.This chapter discusses a modified procedure for lead staining of thin tissue sections, addressing the issues of contamination and instability associated with traditional lead hydroxide solutions. The authors describe the limitations of existing methods, such as the instability of lead hydroxide in air and the difficulty in achieving uniform staining. They propose a new solution that combines sodium hydroxide and potassium sodium tartrate to stabilize the lead salt, preventing precipitation and maintaining clarity even when exposed to air. The modified solution is stable, effective, and does not damage the sections, making it suitable for electron microscopy. The authors provide detailed instructions for preparing and using the solution, including dilution and storage methods. Comparative studies show that the new staining method produces similar results to the original lead hydroxide solution, with the added benefit of reduced contamination and improved clarity.