This study presents a comprehensive molecular phylogeny of living primates, based on genomic sequence data from 186 primates representing 61 genera. The phylogeny, rooted by outgroup species from Dermoptera, Scandentia, and Lagomorpha, is highly resolved and robust, providing new insights into primate evolution and taxonomy. Key findings include the resolution of long-standing taxonomic controversies, such as the placement of Tarsiiformes as sister to Simiiformes, the monophyly of Chiromyiformes and Lemuriformes, and the rapid speciation of Lorisidae. The phylogeny also reveals patterns of genome divergence, rate heterogeneity, and insertion/deletion events, which are informative for understanding human evolution and the emergence of zoonotic diseases. The study's robust framework is essential for comparative genomic investigations and conservation efforts.This study presents a comprehensive molecular phylogeny of living primates, based on genomic sequence data from 186 primates representing 61 genera. The phylogeny, rooted by outgroup species from Dermoptera, Scandentia, and Lagomorpha, is highly resolved and robust, providing new insights into primate evolution and taxonomy. Key findings include the resolution of long-standing taxonomic controversies, such as the placement of Tarsiiformes as sister to Simiiformes, the monophyly of Chiromyiformes and Lemuriformes, and the rapid speciation of Lorisidae. The phylogeny also reveals patterns of genome divergence, rate heterogeneity, and insertion/deletion events, which are informative for understanding human evolution and the emergence of zoonotic diseases. The study's robust framework is essential for comparative genomic investigations and conservation efforts.