The article reviews the emergence and advancements of metabiotics, a new concept in probiotics that combines probiotic components with metabolic by-products to enhance specific physiological functions. Metabiotics, characterized by short-chain fatty acids (SCFAs), bacteriocins, polysaccharides, and peptides, are seen as a safer and more effective alternative to traditional probiotics. They are particularly noted for their health benefits in immune regulation, anti-inflammatory, anticancer, and brain-neurological health. The review highlights the gut-brain axis theory, which links gut microbiota to neurological disorders such as depression, anxiety, autism spectrum disorder, Alzheimer's disease, and Parkinson's disease. Additionally, metabiotics are found to have immunomodulatory and anticancer effects, with potential applications in various diseases. The article concludes by emphasizing the promising future of metabiotics in preventing and treating diseases through their multifaceted health benefits.The article reviews the emergence and advancements of metabiotics, a new concept in probiotics that combines probiotic components with metabolic by-products to enhance specific physiological functions. Metabiotics, characterized by short-chain fatty acids (SCFAs), bacteriocins, polysaccharides, and peptides, are seen as a safer and more effective alternative to traditional probiotics. They are particularly noted for their health benefits in immune regulation, anti-inflammatory, anticancer, and brain-neurological health. The review highlights the gut-brain axis theory, which links gut microbiota to neurological disorders such as depression, anxiety, autism spectrum disorder, Alzheimer's disease, and Parkinson's disease. Additionally, metabiotics are found to have immunomodulatory and anticancer effects, with potential applications in various diseases. The article concludes by emphasizing the promising future of metabiotics in preventing and treating diseases through their multifaceted health benefits.