Stroke induces the long-distance migration of newly born neurons from the subventricular zone (SVZ) to peri-infarct cortex, where they form close associations with remodeling blood vessels in a unique neurovascular niche. This process is driven by the upregulation of stromal-derived factor 1 (SDF1) and angiopoietin 1 (Ang1) in blood vessels, which recruit and guide the migration of these neuroblasts. The study demonstrates that SDF1β and Ang1 promote behavioral recovery during the period of neuroblast migration but do not affect the long-term survival of regenerated neurons. These findings define a novel neurovascular niche that links angiogenesis and neurogenesis in the context of functional recovery from brain injury.Stroke induces the long-distance migration of newly born neurons from the subventricular zone (SVZ) to peri-infarct cortex, where they form close associations with remodeling blood vessels in a unique neurovascular niche. This process is driven by the upregulation of stromal-derived factor 1 (SDF1) and angiopoietin 1 (Ang1) in blood vessels, which recruit and guide the migration of these neuroblasts. The study demonstrates that SDF1β and Ang1 promote behavioral recovery during the period of neuroblast migration but do not affect the long-term survival of regenerated neurons. These findings define a novel neurovascular niche that links angiogenesis and neurogenesis in the context of functional recovery from brain injury.