A study on neurogenesis after stroke reveals a neurovascular niche that supports the regeneration of neurons. Stroke not only causes cell death but also triggers the birth and migration of new neurons in the area of ischemic damage. The research identifies a unique environment in the peri-infarct cortex where newly born neurons associate with remodeling blood vessels. This environment is linked to angiogenesis through the production of stromal-derived factor 1 (SDF1) and angiopoietin 1 (Ang1). These molecules promote the migration of neuroblasts and behavioral recovery after stroke. The study uses a mouse model of focal stroke in the somatosensory barrel field cortex to show that stroke induces neurogenesis from GFAP-expressing progenitor cells in the subventricular zone (SVZ) and migration of newly born neurons into the neurovascular niche. The niche is characterized by the association of neuroblasts with blood vessels and the upregulation of SDF1 and Ang1. These findings highlight the role of the neurovascular niche in post-stroke neurogenesis and identify molecular mechanisms shared between angiogenesis and neurogenesis during functional recovery. The study also demonstrates that systemic administration of SDF1β and Ang1 improves behavioral recovery during the period of neuroblast migration but does not affect the long-term survival of regenerated neurons. The results suggest that the neurovascular niche in the peri-infarct cortex is a unique environment where angiogenesis and neurogenesis are linked through specific vascular growth factors and chemokines, contributing to behavioral recovery after stroke.A study on neurogenesis after stroke reveals a neurovascular niche that supports the regeneration of neurons. Stroke not only causes cell death but also triggers the birth and migration of new neurons in the area of ischemic damage. The research identifies a unique environment in the peri-infarct cortex where newly born neurons associate with remodeling blood vessels. This environment is linked to angiogenesis through the production of stromal-derived factor 1 (SDF1) and angiopoietin 1 (Ang1). These molecules promote the migration of neuroblasts and behavioral recovery after stroke. The study uses a mouse model of focal stroke in the somatosensory barrel field cortex to show that stroke induces neurogenesis from GFAP-expressing progenitor cells in the subventricular zone (SVZ) and migration of newly born neurons into the neurovascular niche. The niche is characterized by the association of neuroblasts with blood vessels and the upregulation of SDF1 and Ang1. These findings highlight the role of the neurovascular niche in post-stroke neurogenesis and identify molecular mechanisms shared between angiogenesis and neurogenesis during functional recovery. The study also demonstrates that systemic administration of SDF1β and Ang1 improves behavioral recovery during the period of neuroblast migration but does not affect the long-term survival of regenerated neurons. The results suggest that the neurovascular niche in the peri-infarct cortex is a unique environment where angiogenesis and neurogenesis are linked through specific vascular growth factors and chemokines, contributing to behavioral recovery after stroke.