The study investigates the signaling pathway controlling induced systemic resistance (ISR) in Arabidopsis plants when exposed to nonpathogenic, root-colonizing *Pseudomonas fluorescens* bacteria. Unlike classic pathogen-induced systemic acquired resistance (SAR), ISR is independent of salicylic acid accumulation and pathogenesis-related gene activation. Using mutants *jar1* (jasmonate response), *etr1* (ethylene response), and *npr1* (SAR regulatory), the authors demonstrate that ISR requires responsiveness to jasmonate and ethylene and is dependent on NPR1. Methyl jasmonate and the ethylene precursor 1-aminocyclopropane-1-carboxylate (ACC) effectively induce resistance against *P. syringae* tomato in salicylic acid-nonaccumulating plants. The protection induced by these compounds is blocked in *jar1*, *etr1*, and *npr1* plants, indicating that components of the jasmonate and ethylene responses are successively engaged to trigger a defense reaction regulated by NPR1. The authors propose that rhizobacteria-mediated ISR follows a novel signaling pathway involving components from both the jasmonate and ethylene response pathways.The study investigates the signaling pathway controlling induced systemic resistance (ISR) in Arabidopsis plants when exposed to nonpathogenic, root-colonizing *Pseudomonas fluorescens* bacteria. Unlike classic pathogen-induced systemic acquired resistance (SAR), ISR is independent of salicylic acid accumulation and pathogenesis-related gene activation. Using mutants *jar1* (jasmonate response), *etr1* (ethylene response), and *npr1* (SAR regulatory), the authors demonstrate that ISR requires responsiveness to jasmonate and ethylene and is dependent on NPR1. Methyl jasmonate and the ethylene precursor 1-aminocyclopropane-1-carboxylate (ACC) effectively induce resistance against *P. syringae* tomato in salicylic acid-nonaccumulating plants. The protection induced by these compounds is blocked in *jar1*, *etr1*, and *npr1* plants, indicating that components of the jasmonate and ethylene responses are successively engaged to trigger a defense reaction regulated by NPR1. The authors propose that rhizobacteria-mediated ISR follows a novel signaling pathway involving components from both the jasmonate and ethylene response pathways.