This randomized controlled trial aimed to evaluate the effectiveness of a reengineered hospital discharge program in reducing hospital utilization and rehospitalization rates. The program, called the Reengineered Discharge (RED) intervention, included a nurse discharge advocate and a clinical pharmacist working together to coordinate hospital discharge, educate patients, and reconcile medications. The study was conducted at an urban, academic, safety-net hospital in Boston, with 749 English-speaking hospitalized adults as participants. The primary outcome was the rate of hospital utilization within 30 days of discharge, measured as the number of emergency department visits and readmissions per participant. Secondary outcomes included self-reported preparedness for discharge and frequency of primary care provider follow-up within 30 days. The results showed that the intervention group had a lower rate of hospital utilization compared to the usual care group (0.314 vs. 0.451 visit per person per month; incidence rate ratio, 0.695 [95% CI, 0.515 to 0.937]; P = 0.009). The intervention was most effective among participants with high hospital utilization in the 6 months before admission (P = 0.014). The intervention also improved patient self-reported preparedness for discharge and increased primary care provider follow-up rates. The study concluded that a comprehensive discharge intervention, including patient education, comprehensive discharge planning, and postdischarge reinforcement, can reduce unnecessary hospital utilization and improve patient outcomes. The intervention required about 1.5 hours of nursing time and 30 minutes of pharmacist time per participant, resulting in a cost savings of $412 per person who received the intervention. However, the study had limitations, including its single-center design and reliance on participant self-report for some outcomes.This randomized controlled trial aimed to evaluate the effectiveness of a reengineered hospital discharge program in reducing hospital utilization and rehospitalization rates. The program, called the Reengineered Discharge (RED) intervention, included a nurse discharge advocate and a clinical pharmacist working together to coordinate hospital discharge, educate patients, and reconcile medications. The study was conducted at an urban, academic, safety-net hospital in Boston, with 749 English-speaking hospitalized adults as participants. The primary outcome was the rate of hospital utilization within 30 days of discharge, measured as the number of emergency department visits and readmissions per participant. Secondary outcomes included self-reported preparedness for discharge and frequency of primary care provider follow-up within 30 days. The results showed that the intervention group had a lower rate of hospital utilization compared to the usual care group (0.314 vs. 0.451 visit per person per month; incidence rate ratio, 0.695 [95% CI, 0.515 to 0.937]; P = 0.009). The intervention was most effective among participants with high hospital utilization in the 6 months before admission (P = 0.014). The intervention also improved patient self-reported preparedness for discharge and increased primary care provider follow-up rates. The study concluded that a comprehensive discharge intervention, including patient education, comprehensive discharge planning, and postdischarge reinforcement, can reduce unnecessary hospital utilization and improve patient outcomes. The intervention required about 1.5 hours of nursing time and 30 minutes of pharmacist time per participant, resulting in a cost savings of $412 per person who received the intervention. However, the study had limitations, including its single-center design and reliance on participant self-report for some outcomes.