A Review of Coronavirus Disease-2019 (COVID-19)

A Review of Coronavirus Disease-2019 (COVID-19)

13 March 2020 | Tanu Singhal
A review of the 2019 novel coronavirus (2019-nCoV), now known as SARS-CoV-2, highlights its emergence in Wuhan, China, and subsequent global spread. The virus, which originated in bats and was transmitted to humans through an unknown intermediary, caused severe respiratory illness with symptoms including fever, cough, and shortness of breath. It spreads through respiratory droplets and can be transmitted by asymptomatic individuals. The case fatality rate is estimated at 2-3%, with higher risks for the elderly and those with pre-existing conditions. Diagnosis involves molecular testing of respiratory samples, and CT scans often show abnormalities even in asymptomatic patients. Treatment is primarily supportive, with no approved antiviral drugs. Prevention includes isolation of suspected cases and strict infection control measures in healthcare settings. The virus spreads more rapidly than SARS-CoV and MERS-CoV but has a lower fatality rate. The global impact remains uncertain, with cases increasing exponentially, leading to widespread travel restrictions and public health measures. The virus has affected various populations, with milder symptoms reported outside China. The disease is highly contagious, with transmission possible before symptoms appear. The basic reproduction number (R0) is estimated between 2 and 6.47. The virus can survive on surfaces for days but is inactivated by common disinfectants. It can also be transmitted via the fecal-oral route. Neonatal and pediatric cases are generally milder. There is no approved treatment, and research is ongoing. Prevention is crucial, with emphasis on isolation, hygiene, and public health measures. The virus has challenged global health systems, and future zoonotic outbreaks are likely. The article emphasizes the need for ongoing research, public awareness, and global cooperation to manage the outbreak.A review of the 2019 novel coronavirus (2019-nCoV), now known as SARS-CoV-2, highlights its emergence in Wuhan, China, and subsequent global spread. The virus, which originated in bats and was transmitted to humans through an unknown intermediary, caused severe respiratory illness with symptoms including fever, cough, and shortness of breath. It spreads through respiratory droplets and can be transmitted by asymptomatic individuals. The case fatality rate is estimated at 2-3%, with higher risks for the elderly and those with pre-existing conditions. Diagnosis involves molecular testing of respiratory samples, and CT scans often show abnormalities even in asymptomatic patients. Treatment is primarily supportive, with no approved antiviral drugs. Prevention includes isolation of suspected cases and strict infection control measures in healthcare settings. The virus spreads more rapidly than SARS-CoV and MERS-CoV but has a lower fatality rate. The global impact remains uncertain, with cases increasing exponentially, leading to widespread travel restrictions and public health measures. The virus has affected various populations, with milder symptoms reported outside China. The disease is highly contagious, with transmission possible before symptoms appear. The basic reproduction number (R0) is estimated between 2 and 6.47. The virus can survive on surfaces for days but is inactivated by common disinfectants. It can also be transmitted via the fecal-oral route. Neonatal and pediatric cases are generally milder. There is no approved treatment, and research is ongoing. Prevention is crucial, with emphasis on isolation, hygiene, and public health measures. The virus has challenged global health systems, and future zoonotic outbreaks are likely. The article emphasizes the need for ongoing research, public awareness, and global cooperation to manage the outbreak.
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[slides and audio] A Review of Coronavirus Disease-2019 (COVID-19)