This review article provides an overview of the antimicrobial, antiviral, and antifungal activities of curcumin, a polyphenolic compound derived from *Curcuma longa* (turmeric). Curcumin has been extensively studied for its broad-spectrum antimicrobial properties, including antibacterial, antiviral, and antifungal activities. The review highlights the potential of curcumin as a natural antimicrobial agent, particularly in combination with other antimicrobial agents to enhance their effectiveness and reduce side effects. Curcumin has shown promise in treating bacterial infections, viral diseases, and fungal infections, with some studies demonstrating synergistic effects when combined with antibiotics, antiviral drugs, and antifungal agents. The review also discusses the challenges in improving the bioavailability and solubility of curcumin to enhance its antimicrobial activities, including the use of nanocarriers and heat treatment. Despite its extensive research, curcumin's clinical applications are still limited, and further studies are needed to fully explore its therapeutic potential.This review article provides an overview of the antimicrobial, antiviral, and antifungal activities of curcumin, a polyphenolic compound derived from *Curcuma longa* (turmeric). Curcumin has been extensively studied for its broad-spectrum antimicrobial properties, including antibacterial, antiviral, and antifungal activities. The review highlights the potential of curcumin as a natural antimicrobial agent, particularly in combination with other antimicrobial agents to enhance their effectiveness and reduce side effects. Curcumin has shown promise in treating bacterial infections, viral diseases, and fungal infections, with some studies demonstrating synergistic effects when combined with antibiotics, antiviral drugs, and antifungal agents. The review also discusses the challenges in improving the bioavailability and solubility of curcumin to enhance its antimicrobial activities, including the use of nanocarriers and heat treatment. Despite its extensive research, curcumin's clinical applications are still limited, and further studies are needed to fully explore its therapeutic potential.