This review discusses recent trends and future developments in electrochemical sensing, highlighting the advancements in electrode materials and sensing methods. Two-dimensional (2D) materials such as graphene, metal-organic frameworks (MOFs), MXenes, and transition metal dichalcogenides (TMDCs) have shown significant potential in improving selectivity, sensitivity, and detection limits. These materials offer enhanced performance in wearable and point-of-care (POC) electrochemical sensors, which are becoming increasingly important for real-time monitoring and analysis. The review also covers various analytical techniques, including voltammetry, amperometry, and potentiometry, and their applications in heavy metal detection, enzymatic and nonenzymatic glucose sensing, pesticide detection, and antibiotic monitoring. Additionally, it explores the development of wearable and textile-based sensors, emphasizing their advantages in minimally invasive and decentralized chemical analysis. The challenges and future directions in electrochemical sensing are also discussed, focusing on the need for cost-effectiveness, selectivity, and miniaturization to meet the demands of wearable and POC applications.This review discusses recent trends and future developments in electrochemical sensing, highlighting the advancements in electrode materials and sensing methods. Two-dimensional (2D) materials such as graphene, metal-organic frameworks (MOFs), MXenes, and transition metal dichalcogenides (TMDCs) have shown significant potential in improving selectivity, sensitivity, and detection limits. These materials offer enhanced performance in wearable and point-of-care (POC) electrochemical sensors, which are becoming increasingly important for real-time monitoring and analysis. The review also covers various analytical techniques, including voltammetry, amperometry, and potentiometry, and their applications in heavy metal detection, enzymatic and nonenzymatic glucose sensing, pesticide detection, and antibiotic monitoring. Additionally, it explores the development of wearable and textile-based sensors, emphasizing their advantages in minimally invasive and decentralized chemical analysis. The challenges and future directions in electrochemical sensing are also discussed, focusing on the need for cost-effectiveness, selectivity, and miniaturization to meet the demands of wearable and POC applications.